Abstract
Coumarin is a naturally occurring compound widely present in plants and microorganisms, it finds extensive use in perfumery industry. Although a large number of coumarin derivatives have been reported to have diverse biological activities1,2, the main focus appears to be on the anticoagulant action of some of the coumarin analogues3. The extensive work carried out by Lake and coworkers4 has highlighted the toxicity of coumarin compounds due to the double bond between C-3 and C-4 in them. These studies have established the formation of a 3,4-epoxide, the products arising out of the scission of the epoxide moiety and their interactions with cellular macromolecules resulting in the toxic action of the parent coumarins4. 4Methylcoumarins which occur in the edible plant fenugreek (Trigonella foenumgraecum) and other edible and medicinal plants5–12 show a wide range of biological activities and are relatively nontoxic even at higher doses13–17 For the past several years, we have concentrated on the mode of biological action of substituted 4-methylcoumarins with emphasis on the behavior of their hydroxy and acetoxy substituted analogues.
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Parmar, V.S., Raj, H.G., Prasad, A.K., Jain, S.C., Olsen, C.E., Watterson, A.C. (2002). Seminal Findings on a Novel Enzyme: Mechanism of Biochemical Action of 4-Methylcoumarins, Constituents of Medicinal and Edible Plants. In: Şener, B. (eds) Biodiversity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9242-0_12
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DOI: https://doi.org/10.1007/978-1-4419-9242-0_12
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