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Identification, Regulation and Function of Lox-1, a Novel Receptor for Ox-Ldl

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Book cover Atherosclerosis, Hypertension and Diabetes

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 8))

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Abstract

Oxidatively modified low-density lipoprotein (ox-LDL) causes endothelial activa-tion, dysfunction and injury, which are considered primary steps in atherogenesis. Recently, a novel lectin-like receptor for ox-LDL (LOX-1) has been identified, primarily in endothe-lial cells. This receptor mediates uptake of ox-LDL into the endothelial cells and activates a variety of signal transduction mechanisms that lead to endothelial cell activation and expres-sion of adhesion molecules. LOX-1 receptor is transcriptionally upregulated by various stimuli accompanying pathogenic states, including TNF-OC, angiotensin II, shear stress and ox-LDL itself. LOX-1 receptor expression has been demonstrated in animal models and humans with hypertension, diabetes mellitus and atherosclerosis. Expression of this receptor may also be pathogenically involved in arterial thrombosis and myocardial ischemia-reperfusion injury. Understanding the regulation and signal transduction pathways of this receptor may lead to new therapies in prevention and treatment of atherosclerosis, and its complications.

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Author information

Authors and Affiliations

  1. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR, USA

    Jacob Joseph MD

  2. Supported by a Merit Review Award from the VA Central Office, Washington D.C.

    Dayuan Li MD, PHD

  3. a contract with the Department of Defense, Washington, DC

    Hongjiang Chen MD

  4. a Scientist Development Grant from the American Heart Association, Dallas, Texas

    Jawahar L. Mehta MD, PHD, FACC

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  1. Jacob Joseph MD
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  2. Dayuan Li MD, PHD
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  4. Jawahar L. Mehta MD, PHD, FACC
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Editors and Affiliations

  1. Division of Stroke & Vascular Disease, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

  2. Department of Medicine, Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano MD, PhD (Professor Emeritus) (Professor Emeritus)

  3. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Peter Zahradka PhD (Associate Professor) & Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Associate Professor) &  (Distinguished Professor and Director)

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Joseph, J., Li, D., Chen, H., Mehta, J.L. (2003). Identification, Regulation and Function of Lox-1, a Novel Receptor for Ox-Ldl. In: Pierce, G.N., Nagano, M., Zahradka, P., Dhalla, N.S. (eds) Atherosclerosis, Hypertension and Diabetes. Progress in Experimental Cardiology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9232-1_6

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