Brain Na,K-ATPase Enzymatic Activity and Cardiovascular Regulation

  • Mary-Anne H. Kent
  • JAMES W. VAN Huysse
  • Frans H. H. Leenen
Chapter
Part of the Progress in Experimental Cardiology book series (PREC, volume 8)

Abstract

Na,K-ATPase enzymatic activity, by maintaining intracellular cation homeostasis regulates many cellular functions. This review focuses on the role of brain Na,K-ATPase activity in cardiovascular regulation. Na,K-ATPase activity in cardiovascular/osmo-regulatory nuclei may regulate cardiovascular function by modulating neurotransmitter release and/or cell responsiveness. Inhibition of Na,K-ATPase activity in cardiovascular/osmo-regulatory nuclei increases blood pressure and causes hypertension. Inversely, an increase in Na,K-ATPase activity in nuclei involved in cardiovascular/osmo-regulation decreases blood pressure in normotensive and hypertensive rats. A decrease in brain Na, K-ATPase activity is associated with several cardiovascular diseases such as salt-sensitive hypertension, heart failure post myocardial infarction (MI) and hypertension induced by suprarenal aortic constriction (SRC). In hyper-tension induced by SRC, brain Na,K-ATPase isozyme expression and activity decrease in the early phase but increase in the established phase of the hypertension. The decrease in brain Na,K-ATPase activity in salt-sensitive hypertension appears to be mediated by a direct inhibitory action of brain ouabain-like-compounds (OLCs) and reflects mainly a decrease in OC2/GC3 isozyme activity. In rats post MI, brain OLCs decrease both (Xi and a2/OC3 Na,K-ATPase isozyme activity by direct and indirect mechanisms that may not involve a change in expres-sion. Brain OLCs may indirectly modulate Na,K-ATPase activity by increasing the release of neurotransmitters such as NE and ACh that regulate Na,K-ATPase activity. The neurotransmitters involved in mediating the changes in Na,K-ATPase activity in rats post MI or in hypertension are not yet known. However, these studies suggest that brain a2/OC3 as well as C*! Na,K-ATPase isozymes may play a role in the central control of the circulation.

Key words

Na K-ATPase enzymatic activity αsubunit isoform expression Cardiovascular regulation Endogenous ouabain-like-compounds 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Mary-Anne H. Kent
  • JAMES W. VAN Huysse
    • 1
  • Frans H. H. Leenen
    • 2
  1. 1.Hypertension UnitHypertension Unit, University of Ottawa Heart InstituteOttawaCanada
  2. 2.Hypertension UnitHypertension Unit, University of Ottawa Heart InstituteOttawaCanada

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