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Potential Role of Cysteinyl Leukotrienes in Trafficking and Survival of Hematopoietic Progenitor Cells

  • Andreas M. Boehmler
  • Claudio Denzlinger
  • Lothar Kanz
  • Robert Möhle
Chapter
  • 139 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

In the clinical setting of a stem cell transplantation, progenitor and stem cells within the bone marrow (BM) can be mobilized into the donors’ peripheral blood by administration of hematopoietic growth factors. Since these cells retain the ability to repopulate the hematopoietic compartment of the bone marrow (a process referred to as ‘homing’), they can account for hematopoietic recovery within the patient [1]. Thus both mobilization to the peripheral blood and homing back to the bone marrow crucially depend on the extensive migratory capabilities of hematopoietic stem and progenitor cells (HPC).

Keywords

Hematopoietic Progenitor Cell Transendothelial Migration Bone Marrow Microenvironment Hematopoietic Growth Factor Hematopoietic Recovery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Andreas M. Boehmler
    • 1
  • Claudio Denzlinger
    • 2
  • Lothar Kanz
    • 3
  • Robert Möhle
    • 3
  1. 1.Department of Medicine IIUniversity of TübingenTübingenGermany
  2. 2.Department of Internal Medicine IIIMarienhospital StuttgartStuttgartGermany
  3. 3.Department of Medicine II, (Hematology, Oncology, Immunology, Rheumatology),University of TübingenTübingenGermany

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