Potential Role of Cysteinyl Leukotrienes in Trafficking and Survival of Hematopoietic Progenitor Cells
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In the clinical setting of a stem cell transplantation, progenitor and stem cells within the bone marrow (BM) can be mobilized into the donors’ peripheral blood by administration of hematopoietic growth factors. Since these cells retain the ability to repopulate the hematopoietic compartment of the bone marrow (a process referred to as ‘homing’), they can account for hematopoietic recovery within the patient . Thus both mobilization to the peripheral blood and homing back to the bone marrow crucially depend on the extensive migratory capabilities of hematopoietic stem and progenitor cells (HPC).
KeywordsHematopoietic Progenitor Cell Transendothelial Migration Bone Marrow Microenvironment Hematopoietic Growth Factor Hematopoietic Recovery
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