Lipoxins and Aspirin-Triggered Lipoxins in Airway Responses
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Leukotrienes (LT) and prostaglandins (PG) have been implicated as proinflammatory mediators in asthma , while lipoxins (LX) are a distinct class of eicosanoids that carry unique counter-regulatory actions . Analyses of the time course of appearance of eicosanoids during acute inflammation has revealed the early coordinate appearance of LT and PG with leukocyte recruitment followed by LX during resolution . LX’s are generated in human tissues, including airways , and can interact with at least two classes of receptors, CysLT1 and LXA4 receptors (designated ALX) . LX’s, aspirin-triggered 15-epimer-LX’s and stable, longer-acting analogs of these compounds can promote resolution of cytokine-driven acute inflammation , inhibit LTC4-stimulated airway hyper-responsiveness in human asthmatics  and block LTD4-initiated constriction of airway smooth muscle in vitro . of note, aspirin-tolerant asthmatic individuals have a decreased biosynthetic capacity for LX’s . In view of these intriguing findings, we determined the impact of LX’s in an experimental murine model of asthma .
KeywordsAirway Smooth Muscle Lipid Mediator Human Asthmatic Aerosol Challenge Experimental Murine Model
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