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Increased Isoprostanes in Children of Smoking Parents

  • Helmut Sinzinger
  • Anthony Oguogho
  • Heidemarie Pilz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Experimental tobacco smoking (ETS) is attracting increasing attention [1] as a potential risk factor for the development of atherosclerosis [[2],[3]]. Assessment of ETS under real life conditions of biochemical changes is difficult. We therefore assessed the isoprostane 8-epi-PGF in children of parents diagnosed for familial hyperlipoproteinemia at the receptor level with the aim to clarify whether parental smoking may have an influence.

Keywords

Passive Smoking Smoking Parent Blood Withdrawal Real Life Condition Platelet Thromboxane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Barinaga-Burch S, Bergmann J. Tobacco, a legal and policy issue for the elderly. Clearinghouse Review 1996; 30: No 6.Google Scholar
  2. 2.
    Kawachi I, Colditz GA, Speizer FE, Manson JE, Stampfer MI, Willet WC, Hennekens CH. A prospective study of passive smoking and coronary heart disease. Circulation 1997; 95:2374–2379.PubMedCrossRefGoogle Scholar
  3. 3.
    He J, Vupputuri S, Allen K, Prerost MR, Hughes J, Whelton PK. Passive smoking and risk of coronary heart disease: A meta-analysis of epidemiologic studies. N Engl J Med 1999; 340: 920–926.PubMedCrossRefGoogle Scholar
  4. 4.
    Kritz H, Schmid P, Karanikas G, Pirich C, Stamatopoulos Y, Peskar BA, Sinzinger H. Passive smoking increases platelet thromboxane. Int J Angiol 1996; 5: 134–139.CrossRefGoogle Scholar
  5. 5.
    Kritz H, Sinzinger H. Passive smoking, platelet function and atherosclerosis. Wr klin Wschr 1996; 108: 582–588.Google Scholar
  6. 6.
    Morrow JD, Frej B, Atkinson AW, Gaiano M, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts JLII. Increase in circulating products of lipid peroxidation (2-isoprostanes) in smokers. Smoking as cause of oxidant damage. N Engl J Med 1995; 332:1198–1203.PubMedCrossRefGoogle Scholar
  7. 7.
    Oguogho A, Mehrabi M, Sinzinger H. Increased plasma, serum and urinary 8-epi-prostaglandin F in heterozygous hypercholesterolemia. Wr klin Wschr 1999; 111: 113–118.Google Scholar
  8. 8.
    Oguogho A, Kritz H, Sinzinger H. Single exposure to passive smoking does not induce detectable oxidation of low-density lipoproteins. Wr klin Wschr. 1996; 108: 589–592.Google Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Helmut Sinzinger
    • 1
  • Anthony Oguogho
    • 2
  • Heidemarie Pilz
    • 3
  1. 1.Wi/helm Auerswald Atherosclerosis Research GroupViennaAustria
  2. 2.Department of Nuclear MedicineUniversity of ViennaViennaAustria
  3. 3.Department of Internal MedicineKaiserin-Elisabeth HospitalViennaAustria

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