Variable Influence of Statins on Isoprostanes in Hyperlipidemia

  • Helmut Sinzinger
  • Anthony Oguogho
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)


Although statin therapy under normal circumstances reduces oxidation injury, the isoprostane 8-epi-PGF may increase various time intervals after initiation of treatment in certain patients for unknown reason. All statins seem to be equally affected. Stopping statin therapy causes reversal within about 2 weeks. During and after exercise the 8-epi-PGF increase is more frequent. Isoprostanes may become relevant to discover a statin side effect. The pathophysiological and clinical consequences of this finding need to be elaborated.


Statin Therapy Oxidation Injury Statin Treatment Familial Hypercholesterolemia Paradoxical Increase 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Helmut Sinzinger
    • 1
  • Anthony Oguogho
    • 2
  1. 1.Wilhelm Auerswald Atherosclerosis Research GroupViennaAustria
  2. 2.Department of Nuclear MedicineUniversity of ViennaViennaAustria

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