Abstract
Gliomas are the most common primary brain tumors and account for 40% of all central nervous system neoplasms. Glioblastoma multiforme (GBM) is the most malignant glioma and is characterized by highly infiltrative and neurologically destructive growth patterns. Despite new advances in surgical intervention, radiotherapy, chemotherapy, and a variety of molecular target specific therapies, the median survival of patients with GBM did not change in the last two decades. Today, most GBM patients still die in less than a year [1]. Therefore, it is essential to identify novel molecular targets that may be suitable for treatment and prevention of GBM.
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Golubic, M., Prayson, R.A., Vargo, L., Bondar, J., Barnett, G.H. (2003). Increased Expression of 5-Lipoxygenase In Glioblastoma Multiforme. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_44
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DOI: https://doi.org/10.1007/978-1-4419-9194-2_44
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