Abstract
Oxidation injury has been claimed as one of the key factors in the development of coronary heart disease and chronic heart failure [1,2]. The isoprostane 8-epi-PGF22α is gaining increasing interest as reliable marker of in-vivo oxidation injury [3]. As it causes among others coronary vasoconstriction [4] its pathophysiological role may become even more important. We therefore assessed the isoprostane 8-epi-PGF2α in arteries, veins, heart valves and myocardial tissue immunochemically as well as by immunohistochemistry. Furthermore, 8-epi-PGF2α was determined in plasma and urine of patients with CHD compared to patients with dilated and ischemic CMP.
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Wolfram R, Oguogho A, Palumbo B, Sinzinger H. Enhanced oxidative stress in coronary heart disease and chronic heart failure as indicated by increased 8-epi-PGF2α. J Am Coll Cardiol 2003 (submitted).
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Wolfram, R., Oguogho, A., Palumbo, B., Sinzinger, H. (2003). Evidence for Enhanced Oxidative Stress in Coronary Heart Disease and Chronic Heart Failure. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_42
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DOI: https://doi.org/10.1007/978-1-4419-9194-2_42
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