Evidence for Enhanced Oxidative Stress in Coronary Heart Disease and Chronic Heart Failure
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Oxidation injury has been claimed as one of the key factors in the development of coronary heart disease and chronic heart failure [1,2]. The isoprostane 8-epi-PGF22α is gaining increasing interest as reliable marker of in-vivo oxidation injury . As it causes among others coronary vasoconstriction  its pathophysiological role may become even more important. We therefore assessed the isoprostane 8-epi-PGF2α in arteries, veins, heart valves and myocardial tissue immunochemically as well as by immunohistochemistry. Furthermore, 8-epi-PGF2α was determined in plasma and urine of patients with CHD compared to patients with dilated and ischemic CMP.
KeywordsCoronary Heart Disease Chronic Heart Failure Heart Valve Silicic Acid Coronary Vasoconstriction
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- 7.Wolfram R, Oguogho A, Palumbo B, Sinzinger H. Enhanced oxidative stress in coronary heart disease and chronic heart failure as indicated by increased 8-epi-PGF2α. J Am Coll Cardiol 2003 (submitted).Google Scholar