Identification, Characterization, and Properties of a Class Alpha Microsomal Glutathione S- Transferase
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Cytosolic glutathione (GSH) S-transferases (GST) are dimeric enzymes that exhibit both GSH-dependent conjugation and selenium-independent GSH-peroxidase (NonSe-GPX) activities . of the various GST supergene families, class Alpha GST isozymes have attracted a lot of attention for their role in the conjugation and reduction of cellular lipid peroxidation products, including 4-hydroxy nonenal and lipid hydroperoxides. Morgenstern and his colleagues reported a non-homologous GST, designated as MGST, in rat and human liver microsomes that exhibited both these activities and differed from the cytosolic GSTs in primary structure .
KeywordsHuman Liver Microsome Glutathione Peroxidase Activity Glutathione Transferase Sheep Liver Phospholipid Hydroperoxide Glutathione Peroxidase
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