LDL Receptor-Related Protein Plays An Essential Role In 12/15-Lipoxygenase-Mediated LDL Oxidation By Macrophages
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Lipoxygenase incorporates a molecular oxygen regiospecifically and stereospecifically into unsaturated fatty acids. There are four classes of enzymes in mammalian tissues; 5-, 8-, 12-, and 15-lipoxygenases, named by the number indicating oxygenation site of arachidonic acid as a substrate [1,2]. Among the enzymes, 12-lipoxygenases are widely distributed in various tissues and species, and there are three isoforms: platelet, leukocyte and epidermis types. Since the leukocyte 12-lipoxygenase and 15- lipoxygenase-1 are highly related in their primary structures and enzymological properties, these enzymes are collectively called as 12/15- lipoxygenase .
KeywordsCholesteryl Ester Cholesteryl Linoleate Diffuse Staining Pattern High Density Lipoprotein Receptor Lipoprotein Deficient Serum
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