LDL Receptor-Related Protein Plays An Essential Role In 12/15-Lipoxygenase-Mediated LDL Oxidation By Macrophages

  • Wanpeng Xu
  • Yoshitaka Takahashi
  • Tadao Iwasaki
  • Hiroaki Hattori
  • Tanihiro Yoshimoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)


Lipoxygenase incorporates a molecular oxygen regiospecifically and stereospecifically into unsaturated fatty acids. There are four classes of enzymes in mammalian tissues; 5-, 8-, 12-, and 15-lipoxygenases, named by the number indicating oxygenation site of arachidonic acid as a substrate [1,2]. Among the enzymes, 12-lipoxygenases are widely distributed in various tissues and species, and there are three isoforms: platelet, leukocyte and epidermis types. Since the leukocyte 12-lipoxygenase and 15- lipoxygenase-1 are highly related in their primary structures and enzymological properties, these enzymes are collectively called as 12/15- lipoxygenase [3].


Cholesteryl Ester Cholesteryl Linoleate Diffuse Staining Pattern High Density Lipoprotein Receptor Lipoprotein Deficient Serum 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Wanpeng Xu
    • 1
  • Yoshitaka Takahashi
    • 1
  • Tadao Iwasaki
    • 2
  • Hiroaki Hattori
    • 2
  • Tanihiro Yoshimoto
    • 1
  1. 1.Department of Molecular PharmacologyKanazawa University Graduate School of Medical ScienceKanazawaJapan
  2. 2.Research DepartmentR&D Center, BML Inc.SaitamaJapan

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