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Prostaglandin F Protected Cultured Madin-Darby Canine Kidney Cells from the Development of Apoptosis Induced by 12-O-Tetradecanoyl Phorbol-β- Acetate and Stimulated Synergistically with Nordihydroguaiaretic Acid

  • Kohji Nishimura
  • Hirohumi Tsumagari
  • Asami Morioka
  • Shan Lu
  • Mitsuo Jisaka
  • Tsutomu Nagaya
  • Kazushige Yokota
Chapter
  • 139 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

The arachidonate cascade generates a series of lipid mediators to regulate various biological events through cyclooxygenase (COX) and lipoxygenase (LOX) pathways [[3],[5]]. In addition, both COX and LOX metabolites were reported to play a dual role in regulating cell survival and death depending on certain types of cells or signalling molecules [1,[4]]. However, the cellular mechanism by which these eicosanoids mediate the induction or suppression of apoptosis remains still unclear.

Keywords

MDCK Cell Chicken Embryo Fibroblast Calcium Ionophore A23187 Nordihydroguaiaretic Acid Darby Canine Kidney 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Kohji Nishimura
    • 1
  • Hirohumi Tsumagari
    • 1
  • Asami Morioka
    • 1
  • Shan Lu
    • 1
  • Mitsuo Jisaka
    • 1
  • Tsutomu Nagaya
    • 1
  • Kazushige Yokota
    • 1
  1. 1.Department of Life Science and BiotechnologyShimane UniversityMatsue, ShimaneJapan

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