Abstract
The arachidonate cascade generates a series of lipid mediators to regulate various biological events through cyclooxygenase (COX) and lipoxygenase (LOX) pathways [[3],[5]]. In addition, both COX and LOX metabolites were reported to play a dual role in regulating cell survival and death depending on certain types of cells or signalling molecules [1,[4]]. However, the cellular mechanism by which these eicosanoids mediate the induction or suppression of apoptosis remains still unclear.
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Nishimura, K. et al. (2003). Prostaglandin F2α Protected Cultured Madin-Darby Canine Kidney Cells from the Development of Apoptosis Induced by 12-O-Tetradecanoyl Phorbol-β- Acetate and Stimulated Synergistically with Nordihydroguaiaretic Acid. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_37
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DOI: https://doi.org/10.1007/978-1-4419-9194-2_37
Publisher Name: Springer, Boston, MA
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