Isomerization and Nitro-Oxidation of Arachidonic Acid by NO2
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Free radical-mediated oxidation of arachidonic acid leads to formation of iso-eicosanoids, such as isoprostaglandins, isolevuglandins, hydroperoxides, and other products that could function as markers and/or mediators of oxidative stress initiated by a hydroxyl radical. Much less has been known about modifications of arachidonic acid by reactive nitrogen radicals such as NO2, a major product of NO oxidation in vivo and a component of polluted air and smoke. We studied the reaction of NO2 with arachidonic acid to characterize lipid products and their biological activity and usefulness as markers of NO2 interaction with biological membranes.
KeywordsArachidonic Acid Guanylate Cyclase Reactive Nitrogen Species Nitrogen Dioxide Aqueous Model System
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