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Platelet Activating Factor Receptors

  • A. Marilise Marrache
  • Fernand GobeilJr
  • Sylvie G. Bernier
  • Jana Stankova
  • Marek Rola-Pleszezynski
  • Sanaa Choufani
  • Ghassan Bkaily
  • Annie Bourdeau
  • Martin G. Sirois
  • Alejandro Vazquez-Tello
  • L. Fan
  • Jean-Sebastien Joyal
  • Janos G. Filep
  • Daya R. Varma
  • Alfredo Ribeiro-da-Silva
  • Sylvain Chemtob
Chapter
  • 141 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of newly generated PAF within its producing cells [3]. Separate functions for the intracellular and cell surface receptors are suggested using agents which putatively distinguish them [4, 5]; immediate effects are mediated by cell surface receptors whereas regulation of gene expression are dependent upon intracellular receptors consistent with presence of signaling effectors in nuclei including G proteins, Ca++, kinases and NF-κB [6,6,8]; but intracellular PAF receptors; especially on nuclei, which may explain their presumed involvement in gene regulation [5] has never been explicitly demonstrated. We speculated that PAF receptors exist at the cell nucleus where they induce major pro-inflammatory gene cyclooxygenase-2 (COX-2) expression.

Keywords

Platelet Activate Factor Brain Endothelial Cell Mitogen Activate Protein Kinase Cascade Platelet Activate Factor Receptor Activate Protein Kinase Cascade 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • A. Marilise Marrache
    • 1
  • Fernand GobeilJr
    • 1
  • Sylvie G. Bernier
    • 1
  • Jana Stankova
    • 2
  • Marek Rola-Pleszezynski
    • 2
  • Sanaa Choufani
    • 2
  • Ghassan Bkaily
    • 2
  • Annie Bourdeau
    • 3
  • Martin G. Sirois
    • 3
  • Alejandro Vazquez-Tello
    • 1
  • L. Fan
    • 1
  • Jean-Sebastien Joyal
    • 1
  • Janos G. Filep
    • 4
  • Daya R. Varma
    • 5
  • Alfredo Ribeiro-da-Silva
    • 5
  • Sylvain Chemtob
    • 1
  1. 1.Sainte-Justine HospitalResearch CenterMontrealCanada
  2. 2.Departments of Pediatrics and Cell BiologyUniversite de SherbrookeFleurimontCanada
  3. 3.Montreal Heart InstituteMontrealCanada
  4. 4.Maisonneuve-Rosemont HospitalResearch CenterMontrealCanada
  5. 5.Department of Pharmacology and TherapeuticsMcGill University, McIntyre Medical Sciences BuildingMontrealCanada

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