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LTC4 Production by Eosinophils in Asthmatic Subjects with Alternative Forms of Alox-5 Core Promoter

  • Ömer Kalayci
  • Michael Wechsler
  • Ben Galper
  • Chris Hong
  • Elliot Israel
  • Jeffrey M. Drazen
  • Craig M. Lilly
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Pharmacogenetics is the use of genetic information to determine who will (or will not) respond to a given treatment. In order to have a pharmacogenetic basis, there should be variability in the treatment response. Although there are data on the variability of the treatment response to all classes of medications that are used in the treatment of asthma- i.e., glucocorticoids, teophyllin, β2 agonists and leukotriene modifiers- pharmacogenetic associations have been described only for β2 agonists and leukotriene modifiers [1].

Keywords

Binding Motif Asthmatic Subject Asthmatic Individual Pharmacogenetic Association LTC4 Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Ömer Kalayci
  • Michael Wechsler
    • 1
  • Ben Galper
    • 1
  • Chris Hong
    • 1
  • Elliot Israel
    • 1
  • Jeffrey M. Drazen
    • 2
  • Craig M. Lilly
    • 1
  1. 1.Department of Respiratory and Critical Care MedicineBrigham and Women’s, Hospital, Harvard Medical SchoolMAUSA
  2. 2.Department of MedicineHarvard Medical School, Pulmonary and Critical Care DivisionMassachusettsUSA

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