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Induction of Cyclooxygenase-2 Expression by Fluid Shear Stress in Vascular Endothelial Cells

  • Hiroyasu Inoue
  • Yoji Taba
  • Yoshikazu Miwa
  • Chiaki Yokota
  • Megumi Miyagi
  • Toshiyuki Sasaguri
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Vascular endothelial cells are exposed to a wide variety of biomechanical stimuli including fluid shear stress caused by blood flow. Shear stress modulates several endothelial functions, such as control of vascular tone, maintenance of antithrombotic surfaces, regulation of inflammation, protection against oxidative stresses, and regulation of endothelial cell proliferation and apoptosis.

Keywords

Shear Stress Vascular Endothelial Cell Fluid Shear Stress Laminar Shear Stress mRNA Instability Motif 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Hiroyasu Inoue
    • 1
  • Yoji Taba
    • 2
  • Yoshikazu Miwa
    • 2
  • Chiaki Yokota
    • 3
  • Megumi Miyagi
    • 2
  • Toshiyuki Sasaguri
    • 2
  1. 1.Department of PharmacologyNational Cardiovascular, Center Research InstituteOsakaJapan
  2. 2.Department of Clinical Pharmacology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  3. 3.Cerebrovascular LaboratoryNational Cardiovascular, Center Research InstituteOsakaJapan

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