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Induction of Cyclooxygenase-2 Expression by Fluid Shear Stress in Vascular Endothelial Cells

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Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 525))

Abstract

Vascular endothelial cells are exposed to a wide variety of biomechanical stimuli including fluid shear stress caused by blood flow. Shear stress modulates several endothelial functions, such as control of vascular tone, maintenance of antithrombotic surfaces, regulation of inflammation, protection against oxidative stresses, and regulation of endothelial cell proliferation and apoptosis.

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© 2003 Springer Science+Business Media New York

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Inoue, H., Taba, Y., Miwa, Y., Yokota, C., Miyagi, M., Sasaguri, T. (2003). Induction of Cyclooxygenase-2 Expression by Fluid Shear Stress in Vascular Endothelial Cells. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_29

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  • DOI: https://doi.org/10.1007/978-1-4419-9194-2_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4831-3

  • Online ISBN: 978-1-4419-9194-2

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