Renal Effects of Selective Cyclooxygenase Inhibition in Experimental Liver Disease
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Renal synthesis of vasodilator prostaglandins (PGs) plays a key role in the maintenance of renal function in decompensated cirrhosis [1,2]. In fact, acute PG inhibition with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with cirrhosis and ascites is associated with a significant impairment in renal hemodynamics, sodium excretion, free water clearance and the renal response to furosemide and spironolactone [1-3]. Thus, in clinical practice, patients with decompensated cirrhosis cannot be treated with NSAIDs on a long-term basis because of the high risk of developing renal failure and refractory ascites.
KeywordsUrinary Sodium Excretion Decompensated Cirrhosis Refractory Ascites Free Water Clearance Conventional NSAID
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