Abstract
Salicylic acid (SA) is an effective antipyretic and analgesic agent, yet at therapeutic concentrations exerting these effects SA lacks antiinflammatory action, distinguishing it from non-steroidal antiinflammatory drugs (NSAIDs) and selective inhibitors of prostaglandin H synthase-2 (PGHS-2). Only at concentrations much greater than are required for antipyresis does SA demonstrate antiinflammatory effects. In contrast to acetylsalicylic acid (aspirin), which irreversibly inhibits platelet PGHS-1 by acetylating a serine in the cyclooxygenase active site, SA is a weak inhibitor of platelet PGHS. The distinctive pharmacologic behavior of SA suggests that the molecular basis for its action differs from that of NSAIDs and PGHS-2 inhibitors.
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Aronoff, D.M., Boutaud, O., Marnett, L.J., Oates, J.A. (2003). Inhibition of Prostaglandin H2 Synthases by Salicylate is Dependent on the Oxidative State of the Enzymes. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_25
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DOI: https://doi.org/10.1007/978-1-4419-9194-2_25
Publisher Name: Springer, Boston, MA
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