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Inhibition of Prostaglandin H2 Synthases by Salicylate is Dependent on the Oxidative State of the Enzymes

  • David M. Aronoff
  • Olivier Boutaud
  • Lawrence J. Marnett
  • John A. Oates
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Salicylic acid (SA) is an effective antipyretic and analgesic agent, yet at therapeutic concentrations exerting these effects SA lacks antiinflammatory action, distinguishing it from non-steroidal antiinflammatory drugs (NSAIDs) and selective inhibitors of prostaglandin H synthase-2 (PGHS-2). Only at concentrations much greater than are required for antipyresis does SA demonstrate antiinflammatory effects. In contrast to acetylsalicylic acid (aspirin), which irreversibly inhibits platelet PGHS-1 by acetylating a serine in the cyclooxygenase active site, SA is a weak inhibitor of platelet PGHS. The distinctive pharmacologic behavior of SA suggests that the molecular basis for its action differs from that of NSAIDs and PGHS-2 inhibitors.

Keywords

Salicylic Acid Lipid Hydroperoxide Inhibitory Potency Sodium Salicylate Salicylic Acid Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • David M. Aronoff
    • 1
  • Olivier Boutaud
    • 2
  • Lawrence J. Marnett
    • 3
  • John A. Oates
    • 4
  1. 1.Divisions of Infectious Diseases & Pulmonary/Critical Care MedicineAnn ArborUSA
  2. 2.Division of Clinical PharmacologyVanderbilt UniversityNashvilleUSA
  3. 3.Vanderbilt Institute of Chemical BiologyVanderbilt UniversityNashvilleUSA
  4. 4.Division of Clinical PharmacologyVanderbilt University School of Medicine, The Vanderbilt-Ingram Cancer CenterNashvilleUSA

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