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Regulatory Functions of Prostaglandin E2 Synthases

  • Ichiro Kudo
  • Makoto Murakami
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Prostaglandin (PG) E2, the most common prostanoid with a variety of bioactivities, has been implicated in various pathophysiologies. PGE2 is produced via three sequential enzymatic reactions: release of arachidonic acid (AA) from membrane glycerophospholipids by phospholipase A2 (PLA2), conversion of AA to PGH2 by cyclooxygenase (COX), and isomerization of PGH2 to PGE2 by PGE synthase (PGES). During last few years, multiple PGES enzymes have been identified molecularly. In this report, we will overview the structures, enzymatic properties, expression, cellular functions, and possible in vivo functions of two of these enzymes, membrane-bound PGES (mPGES)-l and cytosolic PGES (cPGES).

Keywords

Arachidonic Acid Granulosa Cell Layer Rheumatoid Synovial Cell Transitional Epithelial Cell Cytosolic GSTs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Ichiro Kudo
    • 1
  • Makoto Murakami
    • 1
  1. 1.Showa UniversityShinagawa-kuJapan

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