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Protection of Cell Membrane from Exogenous PLA2 and Related Inflammatory Stimuli by Membrane-Anchored Lipid Conjugates

  • Saul Yedgar
  • Miron Krimsky
  • Ouri Schwob
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Phospholipase A2 (PLA2) is a super-family of enzymes that hydrolyze cell membrane phospholipids (PL) to produce lysophospholipids (LysoPL) and free fatty acids [for review of the PLA2 types see Ref. 1]. The PLA2 family consists of two main kinds of enzymes: the secreted (sPLA2) and the intracellular ones, which include the cytosolic (cPLA2) and the Ca++- independent (iPLA2) enzymes. While cPLA2 is specific to arachidonic acid (AA)-carrying PL, the others do not exhibit preference for a fatty acyl chain in the PL [2].

Keywords

Hyaluronic Acid Fatty Acyl Chain Secretory Phospholipase Lung Microvascular Endothelial Cell Human Lung Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Saul Yedgar
    • 1
  • Miron Krimsky
    • 1
  • Ouri Schwob
    • 1
  1. 1.Department of BiochemistryHebrew University-Hadassah Medical, SchoolJerusalemIsrael

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