Protection of Cell Membrane from Exogenous PLA2 and Related Inflammatory Stimuli by Membrane-Anchored Lipid Conjugates
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Phospholipase A2 (PLA2) is a super-family of enzymes that hydrolyze cell membrane phospholipids (PL) to produce lysophospholipids (LysoPL) and free fatty acids [for review of the PLA2 types see Ref. 1]. The PLA2 family consists of two main kinds of enzymes: the secreted (sPLA2) and the intracellular ones, which include the cytosolic (cPLA2) and the Ca++- independent (iPLA2) enzymes. While cPLA2 is specific to arachidonic acid (AA)-carrying PL, the others do not exhibit preference for a fatty acyl chain in the PL .
KeywordsHyaluronic Acid Fatty Acyl Chain Secretory Phospholipase Lung Microvascular Endothelial Cell Human Lung Endothelial Cell
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- 1.Dennis EA.The growing phospholipase A2 superfamily of signal transduction enzymes. Trends-Biochem-Sci 1997; 22:1–2.Google Scholar
- 2.Murakami M, Kambe T, Shimbara S, Higashino KI, Hanasaki K, Arita H, Horiguchi M, Arita M, Arai H, Inoue K, Kudo I. Different functional aspects of the group II subfamily (Types IIA and V) and type X secretory phospholipase A2s in regulating arachidonic acid release and prostaglandin generation. Implications of cyclooxygenase-2 induction and phospholipid scramblase-mediated cellular membrane perturbation. J Biol Chem 1999; 274: 31435–31444.PubMedCrossRefGoogle Scholar
- 12.Peilot H, Rosengren B, Bondjers G and Hurt-Camego E. Interferon-gamma induced secretory group IIA phospholipase A2 in human arterial smooth muscle cells. Involvement of cell differentiation, STAT-3 activation and modulation by other cytokines. J Biol Chem 2000; 275:22895–22904.PubMedCrossRefGoogle Scholar
- 13.Ginsburg I and Kohen R. Cell damage in inflammatory and infectious sites might involve a coordinated “cross-talk” among oxidants, microbial haemolysins and amphiphiles, cationic proteins, phospholipases, fatty acids, proteinases and cytokines (An Overview). Free Rad Res 1995; 22:489–517.CrossRefGoogle Scholar
- 19.Zaretzky FR, Pearce-Pratt R and Phillips DM. Sulfated polyanious block Chlamydia trachomatis infection of cervix-derived human epithelia. Infect Immunol 1995; 63:3520–3526Google Scholar
- 20.Yedgar S, Dan P, Dagan A, Ginsburg I, Lossos IS and Breuer R. Control of inflammatory processes by cell-impermeable inhibitions of phospholipase A2. Agents and Actions 1995; S46: 77–84.Google Scholar
- 27.Beck GCh, Hermes WC, Yard BA, Kaszkin M, Von Zabern D, Schulte J, Markus H, Prem K, Krimsky M, Van Ackern K, Van der Woude FG and Yedgar S. Amelioration of endotoxin-induced sepsis in rats by membrane-anchored lipid conjugates. Critical Care Medicine, In Press.Google Scholar