Protection of Cell Membrane from Exogenous PLA2 and Related Inflammatory Stimuli by Membrane-Anchored Lipid Conjugates

  • Saul Yedgar
  • Miron Krimsky
  • Ouri Schwob
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)


Phospholipase A2 (PLA2) is a super-family of enzymes that hydrolyze cell membrane phospholipids (PL) to produce lysophospholipids (LysoPL) and free fatty acids [for review of the PLA2 types see Ref. 1]. The PLA2 family consists of two main kinds of enzymes: the secreted (sPLA2) and the intracellular ones, which include the cytosolic (cPLA2) and the Ca++- independent (iPLA2) enzymes. While cPLA2 is specific to arachidonic acid (AA)-carrying PL, the others do not exhibit preference for a fatty acyl chain in the PL [2].


Hyaluronic Acid Fatty Acyl Chain Secretory Phospholipase Lung Microvascular Endothelial Cell Human Lung Endothelial Cell 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Saul Yedgar
    • 1
  • Miron Krimsky
    • 1
  • Ouri Schwob
    • 1
  1. 1.Department of BiochemistryHebrew University-Hadassah Medical, SchoolJerusalemIsrael

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