Cellular Arachidonate-Releasing Functions of Various Phospholipase A2s
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Phospholipase A2 (PLA2), which hydrolyzes the sn-2 position of glycerophospholipid to liberate free fatty acid and lysophospholipid, occurs in multiple forms in mammals. To date, four major classes of PLA2 enzymes have been identified, including secretory PLA2s (sPLA2s), cytosolic PLA2s (cPLA2s), Ca2+-independent PLA2s (iPLA2s) and platelet-activating factor acetylhydrolases (PAF-AHs). In this paper, we summarize our current understanding of the regulation of cellular arachidonate (AA) metabolism by sPLA2, cPLA2 and iPLA2 enzymes. More details are described in our recent reviews [1,2].
KeywordsAnkyrin Repeat Arachidonic Acid Release Fatty Acid Release Fatty Acid Selectivity Perinuclear Membrane
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