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Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research pp 67–69Cite as

Cytochrome P450 Arachidonic Acid Metabolites Modulate Renal Tubular Function

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 525)

Abstract

Nephron function is segmented. Each segment has characteristic transport mechanisms and individual eicosanoid profiles [1,[2]]. Mapping the distribution of AA metabolizing enzymes within the nephron is essential to understanding the contribution of eicosanoids to excretory function. The study of Bonvalet et al addressed the localization of cyclooxygenase (COX) in the nephron and uncovered large segments that had negligible COX activity, particularly the proximal tubules (PT) and the thick ascending limb (TAL) [[3]], which later studies identified as segments heavily invested with cytochrome monooxygenase (CYP450) activity [[4],[5]].

Keywords

  • Proximal Tubule
  • Arachidonic Acid Metabolite
  • Thick Ascend Limb
  • Excretory Function
  • Renal Tubular Function

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology, New York Medical College, 10595, Valhalla, New York, USA

    Mairead A. Carroll, Nicholas R. Ferreri & John C. McGiff

  2. Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, 07300, Mexico, DF

    Bruno A. Escalante

  3. College of Pharmacy & Health Sciences, Texas Southern University, Houston, Texas, 77004, USA

    Adebayo O. Oyekan

Authors
  1. Mairead A. Carroll
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  2. Nicholas R. Ferreri
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  3. Bruno A. Escalante
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  4. Adebayo O. Oyekan
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  5. John C. McGiff
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Editor information

Editors and Affiliations

  1. University of Istanbul, Istanbul, Turkey

    Zeliha Yazici

  2. University of Milan, Milan, Italy

    Giancarlo C. Folco

  3. Harvard Medical School, Boston, Massachusetts

    Jeffrey M. Drazen

  4. Free University of Berlin, Berlin, Germany

    Santosh Nigam

  5. University of Tokyo, Tokyo, Japan

    Takao Shimizu

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Carroll, M.A., Ferreri, N.R., Escalante, B.A., Oyekan, A.O., McGiff, J.C. (2003). Cytochrome P450 Arachidonic Acid Metabolites Modulate Renal Tubular Function. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_13

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  • DOI: https://doi.org/10.1007/978-1-4419-9194-2_13

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  • Print ISBN: 978-1-4613-4831-3

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