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Cytochrome P450 Arachidonic Acid Metabolites Modulate Renal Tubular Function

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 525)

Abstract

Nephron function is segmented. Each segment has characteristic transport mechanisms and individual eicosanoid profiles [1,[2]]. Mapping the distribution of AA metabolizing enzymes within the nephron is essential to understanding the contribution of eicosanoids to excretory function. The study of Bonvalet et al addressed the localization of cyclooxygenase (COX) in the nephron and uncovered large segments that had negligible COX activity, particularly the proximal tubules (PT) and the thick ascending limb (TAL) [[3]], which later studies identified as segments heavily invested with cytochrome monooxygenase (CYP450) activity [[4],[5]].

Keywords

  • Proximal Tubule
  • Arachidonic Acid Metabolite
  • Thick Ascend Limb
  • Excretory Function
  • Renal Tubular Function

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. McGiff JC, Quilley J. 20-HETE and the kidney: resolution of old problems and new beginnings. Am J Physiol 1999; 277: R607–R623.

    PubMed  CAS  Google Scholar 

  2. Carroll MA, McGiff JC, Ferreri NR. Products of arachidonic acid metabolism. IN: Renal Disease Protocols. Edited by Michael S. Goligorsky. The Humana Press, Inc Totawa, NJ In Press, 2002.

    Google Scholar 

  3. Bonvalet J-P, Pradelles P, Farman N. Segmental synthesis and actions of prostaglandins along the nephron. Am J Physiol 1987; 253:F377–F387.

    PubMed  CAS  Google Scholar 

  4. Omata K, Abraham NG, Schwartzman ML. Renal cytochrome P-450-arachidonic acid metabolism: localization and hormonal regulation in SHR. Am J Physiol 1992; F591–F599.

    Google Scholar 

  5. Carroll MA, Sala A, Dunn CE, McGiff JC, Murphy R.C. Structural identification of cytochrome P450-dependent arachidonate metabolites formed by rabbit medullary thick ascending limb cells. J Biol Chem 1991; 266:12306–12312.

    PubMed  CAS  Google Scholar 

  6. Ferreri NR, Escalante BA, Zhao Y, An S-J, McGiff JC. Angiotensin II induces TNF production by the thick ascending limb: functional implications. Am J Physiol 1998; 274:F148–F155.

    PubMed  CAS  Google Scholar 

  7. Escalante B, Erlij D, Falck JR, McGiff JC. Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle. Science. 1991; 251:799–802.

    PubMed  CrossRef  CAS  Google Scholar 

  8. Lu M, Zhu Y, Balazy M, Reddy KM, Falck JR, Wang W-H. Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney. J Gen Physiol 1996; 108:537–547.

    PubMed  CrossRef  CAS  Google Scholar 

  9. Carroll MA, Balazy M, Margiotta P, Huang D-D, Falck JR, McGiff JC. Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol 1996; 271:R863–R869.

    PubMed  CAS  Google Scholar 

  10. Wang D, An S-J, Wang W-H, McGiff JC, Ferreri NR. CaR-mediated COX-2 expression in primary cultured mTAL cells. Am J Physiol 2001; 281:R658–R664.

    Google Scholar 

  11. Escalante BA, McGiff JC, Oyekan AO. Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule. Am J Physiol 2002; 282:F144–F150.

    CAS  Google Scholar 

  12. Oyekan AO, McGiff JC. Cytochrome P-450-derived eicosanoids participate in the renal functional effects of ET-1 in the anesthetized rat. Am J Physiol 1998; 274:R52–R61.

    PubMed  CAS  Google Scholar 

  13. Schwartzman ML, Falck JR, Yadagiri P, Escalante B. Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. J Biol Chem 1989; 264:11658–11662.

    PubMed  CAS  Google Scholar 

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Carroll, M.A., Ferreri, N.R., Escalante, B.A., Oyekan, A.O., McGiff, J.C. (2003). Cytochrome P450 Arachidonic Acid Metabolites Modulate Renal Tubular Function. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_13

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  • DOI: https://doi.org/10.1007/978-1-4419-9194-2_13

  • Publisher Name: Springer, Boston, MA

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