Cytochrome P450 Arachidonic Acid Metabolites Modulate Renal Tubular Function

  • Mairead A. Carroll
  • Nicholas R. Ferreri
  • Bruno A. Escalante
  • Adebayo O. Oyekan
  • John C. McGiff
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)


Nephron function is segmented. Each segment has characteristic transport mechanisms and individual eicosanoid profiles [1,[2]]. Mapping the distribution of AA metabolizing enzymes within the nephron is essential to understanding the contribution of eicosanoids to excretory function. The study of Bonvalet et al addressed the localization of cyclooxygenase (COX) in the nephron and uncovered large segments that had negligible COX activity, particularly the proximal tubules (PT) and the thick ascending limb (TAL) [[3]], which later studies identified as segments heavily invested with cytochrome monooxygenase (CYP450) activity [[4],[5]].


Proximal Tubule Arachidonic Acid Metabolite Thick Ascend Limb Excretory Function Renal Tubular Function 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Mairead A. Carroll
    • 1
  • Nicholas R. Ferreri
    • 1
  • Bruno A. Escalante
    • 2
  • Adebayo O. Oyekan
    • 3
  • John C. McGiff
    • 1
  1. 1.Department of PharmacologyNew York Medical CollegeValhallaUSA
  2. 2.Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico NacionalDFMexico
  3. 3.College of Pharmacy & Health SciencesTexas Southern UniversityHoustonUSA

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