Cytochrome P450 Arachidonic Acid Metabolites Modulate Renal Tubular Function
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Nephron function is segmented. Each segment has characteristic transport mechanisms and individual eicosanoid profiles [1,]. Mapping the distribution of AA metabolizing enzymes within the nephron is essential to understanding the contribution of eicosanoids to excretory function. The study of Bonvalet et al addressed the localization of cyclooxygenase (COX) in the nephron and uncovered large segments that had negligible COX activity, particularly the proximal tubules (PT) and the thick ascending limb (TAL) [], which later studies identified as segments heavily invested with cytochrome monooxygenase (CYP450) activity [,].
KeywordsProximal Tubule Arachidonic Acid Metabolite Thick Ascend Limb Excretory Function Renal Tubular Function
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