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Cyclooxygenase Activity is Regulated by the Heme Oxygenase System in Microvessel Endothelial Cells

  • Nader G. Abraham
  • Rafal Olszanecki
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Cyclooxygenase(s) catalyzes the oxygenation and peroxidation of arachidonic acid to prostaglandin endoperoxide H2, the immediate precursor of prostaglandins and thromboxane. Two COX isoforms encoded by two related genes have been identified; COX-1 is constitutively expressed and is considered to generate prostaglandins for normal physiological functions whereas COX-2 is, in most tissues, an inducible enzyme expressing rapidly and transiently in response to a variety of stimuli [1]. Both COX isoforms are hemeproteins [[2]. Heme binds to the COX apoenzyme with a stoichiometry of approximately one heme molecule per each subunit [[3]]. It is well documented that the heme prosthetic group of COX is essential for the expression of catalytic activity [[3]]. Accordingly, the possibility arises that variations in the cellular levels of heme impact on the amount of catalytically active COX present in cells.

Keywords

Prostaglandin Production Cyclooxygenase Activity Microvessel Endothelial Cell Prostaglandin Endoperoxide Prostaglandin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Nader G. Abraham
    • 1
  • Rafal Olszanecki
    • 2
  1. 1.New York Medical, CollegeValhallaUSA
  2. 2.Medical College, PharmacologyJagiellonian UniversityCracowPoland

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