Abstract
Cyclooxygenase(s) catalyzes the oxygenation and peroxidation of arachidonic acid to prostaglandin endoperoxide H2, the immediate precursor of prostaglandins and thromboxane. Two COX isoforms encoded by two related genes have been identified; COX-1 is constitutively expressed and is considered to generate prostaglandins for normal physiological functions whereas COX-2 is, in most tissues, an inducible enzyme expressing rapidly and transiently in response to a variety of stimuli [1]. Both COX isoforms are hemeproteins [[2]. Heme binds to the COX apoenzyme with a stoichiometry of approximately one heme molecule per each subunit [[3]]. It is well documented that the heme prosthetic group of COX is essential for the expression of catalytic activity [[3]]. Accordingly, the possibility arises that variations in the cellular levels of heme impact on the amount of catalytically active COX present in cells.
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Abraham, N.G., Olszanecki, R. (2003). Cyclooxygenase Activity is Regulated by the Heme Oxygenase System in Microvessel Endothelial Cells. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_12
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DOI: https://doi.org/10.1007/978-1-4419-9194-2_12
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