Regulation of Renal Microvascular 20- Hydroxyeicosatetraenoic Acid (20-Hete) Levels
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The kidney possesses a large capacity to generate cytochrome P450 (CYP) dependent arachidonic acid (AA) metabolites, chiefly the ω and ω -1 hydroxylase-derived metabolites, 19- and 20- hydroxyeicosatetraenoic acids (HETEs), and lesser amounts of epoxyeicosatrienoic acids (EETs), primarily 11,12 EETs . Angiotensin II (AII) increases renal synthesis of HETEs and EETs, which modulate and mediate the actions of the peptide in the renal vasculature and the nephron []. Our studies have identified preglomerular microvessels (PMGV) as a potentially important site of interactions involving AII and CYP-AA products [,]. The “complex control mechanisms” governing the renal circulation, are funneled into the PMGV. PGMV are the effector component of key renal regulatory mechanisms, autoregulation of renal blood flow and tubuloglomerular feedback []. Renal autoregulation and tubular glomerular feedback are mediated by 20-HETE through constriction of PGMV, particularly afferent arterioles .
KeywordsAfferent Arteriole Prostaglandin Analog Hydroxyeicosatetraenoic Acid Sodium Depletion Tubuloglomerular Feedback
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