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Regulation of Renal Microvascular 20- Hydroxyeicosatetraenoic Acid (20-Hete) Levels

  • Mairead A. Carroll
  • Monica K. Cheng
  • Houli Jiang
  • Anabel B. Doumad
  • Maria F. Capparelli
  • John C. McGiff
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

The kidney possesses a large capacity to generate cytochrome P450 (CYP) dependent arachidonic acid (AA) metabolites, chiefly the ω and ω -1 hydroxylase-derived metabolites, 19- and 20- hydroxyeicosatetraenoic acids (HETEs), and lesser amounts of epoxyeicosatrienoic acids (EETs), primarily 11,12 EETs [1]. Angiotensin II (AII) increases renal synthesis of HETEs and EETs, which modulate and mediate the actions of the peptide in the renal vasculature and the nephron [[2]]. Our studies have identified preglomerular microvessels (PMGV) as a potentially important site of interactions involving AII and CYP-AA products [[3],[4]]. The “complex control mechanisms” governing the renal circulation, are funneled into the PMGV. PGMV are the effector component of key renal regulatory mechanisms, autoregulation of renal blood flow and tubuloglomerular feedback [[5]]. Renal autoregulation and tubular glomerular feedback are mediated by 20-HETE through constriction of PGMV, particularly afferent arterioles [6].

Keywords

Afferent Arteriole Prostaglandin Analog Hydroxyeicosatetraenoic Acid Sodium Depletion Tubuloglomerular Feedback 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Mairead A. Carroll
    • 1
  • Monica K. Cheng
    • 1
  • Houli Jiang
    • 1
  • Anabel B. Doumad
    • 1
  • Maria F. Capparelli
    • 1
  • John C. McGiff
    • 1
  1. 1.Department of PharmacologyNew York Medical CollegeValhallaUSA

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