Abstract
Injury to the corneal surface evokes an inflammatory reaction which includes the release of arachidonic acid (AA) and, subsequently, the production of eicosanoids which have been implicated as inflammatory mediators. These eicosanoids are produced by cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 monooxygenases (CYP). We have identified CYP as a primary inflammatory pathway in the corneal epithelium where it metabolizes AA to 12-hydroxyeicosanoids, primarily 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid [12-(R)-HETE] and 12(R)- hydroxy-5,8,14-eicosatrienoic acid [12(R)-HETrE]; both metabolites exhibit biological activities that are typical of inflammatory mediators including increased membrane permeability, vasodilation, Chemotaxis and angiogenesis. Indeed, numerous studies provided evidence that these metabolites are critical tissue-derived mediators of ocular surface inflammation.
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Laniado-Schwartzman, M., Dunn, M.W. (2003). Cytochrome P450-Derived Eicosanoids are Mediators of Ocular Surface Inflammation. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_10
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DOI: https://doi.org/10.1007/978-1-4419-9194-2_10
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