Abstract
The intravenous anaesthetic propofol is frequently used as mono-anaesthetic/sedative for a range of small surgical procedures in patients who breathe spontaneously or is combined with regional anaesthesia for larger surgical procedures. Like the inhalational anaesthetics, propofol has a considerable effect on the ventilatory control system, reducing the ventilatory responses to carbon dioxide and hypoxia; induction doses of propofol (1.5 to 2.5 mg/kg) cause the cessation of breathing activity when infused rapidly. These effects may be related to direct effects of propofol at peripheral(e.g., peripheral chemoreceptors, lung, diaphragm) and/or central sites(e.g., central chemoreceptors, respiratory centres, centres involved in blood pressure control) and/or to indirect effects at sites involved in the control of vigilance/arousal/wakefulness. For example, animal studies indicate that propofol causes an inhibitory effect on areas of the dorsomedial and ventrolateral medulla, which contain the central chemoreceptors and centres controlling pressor responses.1
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Dahan, A., Nieuwenhuijs, D.J., Olofsen, E. (2003). Influence of Propofol on the Control of Breathing. In: Vuyk, J., Schraag, S. (eds) Advances in Modelling and Clinical Application of Intravenous Anaesthesia. Advances in Experimental Medicine and Biology, vol 523. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9192-8_8
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DOI: https://doi.org/10.1007/978-1-4419-9192-8_8
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