Abstract
Positron Emission Tomography (PET) and functional Magnetic Resonance Imaging (fMRI) allow researchers to study brain function in vivo. These techniques are used to refine our understanding of the nature of anaesthetic effects as well as of the influence of anaesthetic drugs on sensory and pain transmission.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M. Raichle, W. Martin, Herscovitch P, Mintun M, Markham J, Brain blood flow measured with intravenous H2O15 II. Implementation and validation, JfNucl Med 24, 790–8, (1983)
M. Kato, Ueno T, Black P, Regional cerebral blood flow of the main visual pathways during photic stimulation of the retina in intact and split-brain monkeys, Exp Neurol 42, 65–77 (1974)
A. Villringer, Understanding functional neuroimaging methods based on neurovascular coupling, Adv Exp Med Biol 413, 177–93(1997).
G.B. Saha, Maclntyre W.J, Go R.T., Radiopharmaceuticals for brain imaging, Semin Nucl Med 24, 324–49 (1994)
M.I. Posner, Petersen S.E., Fox P.T., Raichle M.E., Localization of cognitive operations in the human brain, Science 240, 1627–31(1988)
D. Le Bihan, Jezzard P, Haxby J, Sadato N, Rueckert L, Mattay V, Fuctional magnetic resonance imaging of the brain, Annals of Internal Medicine 122, 296–303 (1995).
S. Ogawa, Tank D.W., Menon R., Ellermann J.M., Kim S-G, Merkle H, Ugurbil K, Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging, Proc Natl Acad Sci 89, 5951–5 (1992).
M.T. Alkire, Haier R.J., Barker S.J., Shah N.K., Wu J.C., Kao J., Cerebral metabolism during propofol anesthesia in humans studied with positron emission tomography, Anesthesiology 82, 393–403 (1995).
M.T. Alkire, Quantitative EEG correlations with brain glucose metabolic rate during anesthesia volunteers, Anesthesiology 89, 323–33 (2001).
P. Fiset P, Paus T., Daloze T., Plourde G., Meuret P., Bonhomme V., Hajj-Ali N., Backman SB., Evans A.C., Brain mechanisms of propofol-induced loss of consciousness in humans: a Positron Emission Tomography study, J Neurosci 19, 5506–13 (1999).
R.A. Veselis, Reinsel R.A., Beattie B.J., Mawlawi O.R., Feshchenko V.A., DiResta G.R., Larson S.M., Blasberg R.G., Midazolam changes cerebral blood flow in discrete brain regions, Anesthesiology 87, 1106–17 (1997).
M.T. Alkire, Haier R.J., Fallon J.H., Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurrophysiologic basis of anesthetic-induced unconsciousness, Consciousness and Cognition 9, 370–86 (2000).
R.C. Coghill, Talbot J.D., Evans A.C., Meyer E., Gjedde A., Bushnell M.C., Duncan G.H., Distributed processing of pain and vibration by the human brain, J Neurosci 14, 4095–108 (1994).
J.D. Talbot, Marret S, Evans A.C., Meyer E, Bushnell M.C., Duncan G.H., Multiple representations of pain in human cerebral cortex, Science 251, 1355–7 (1991).
V. Bonhomme, Fiset P, Meuret P, Backman S, Plourde G, Paus T, Bushnell C, Evans A, Effect of propofol-induced general anesthesia on changes in regional cerebral blood flow elicited by vibrotactile stimulation: a positron emission tomography study, J Neurophysiol 85, 1299–308 (2001).
R.K. Hofbauer, Fiset P, Plourde G, Backman S.B., Bushnell M.C., Cortical correlates of the conscious experience of pain, J Neurosci, Submitted (2002).
F. Gyulai, L. Firestone, J. Price, P. Winter, In vivo imaging of volatile anesthetic action at the 5HT2A- receptor (5HT 2 a-R) in humans: a quantitative positron emission tomography (PET) study, Society for Neuroscience 23, 59.18 (1997).
F.E. Gyulai, Mintum M.A., Firestone L.L., Dose-dependent enhancement of in vivo GABAA-benzodiazepine receptor binding by isoflurane, Anesthesiology 95, 585–93 (2001).
S.L. Dewey, Brodie J.D., Fowler J.S., MacGregor R.R., Schyler D.J., King P.T., Alexoff D.L., Volkow N.D., Shiue C-L, Wolf A.P., Bendriem B, Positron Emission Tomography (PET) studies of dopaminergic/cholinergic interactions in the baboon brain, Synapse 6, 321–7 (1990).
U. Ebert, Oertel R, Kirch W: Physostigmine reversal of midazolam-induced electroencephalographic changes in healthy subjects, Clin Pharmacol Ther 67, 538–48 (2001).
A.A. Artru, Hui GS, Physostigmine reversal of general anesthesia for intraoperative neurological testing: Associated EEG changes, Anesth Analg 65, 1059–62, (1986).
P. Hartvig, Lindstrbm B, Petterson E, Wiklund L, Reversal of postoperative somnolence using a two-rate infusion of physostigmine, Acta Anaesthesiol Scand 33, 681–5 (1986).
P. Meuret, Backman S.B., Bonhomme V., Plourde G, Fiset P, Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers, Anesthesiology 93, 708–17 (2000).
A. Toro-Matos, Rendon-Platas A.M, Avila-Valdez E., Villarreal-Guzman R.A., Physostigmine antagonizes ketamine, Anesth Analg 59, 764–7 (1980).
M. Talbot, G. Plourde, S.B. Backman, D. Chartrand, P. Fiset, Effect of physostigmine on the loss of consciousness and analgesia produced by remifentanil, Anesthesiology 93, A389 (2000).
R. Lydic R, Biebuyck JF, Sleep neurobiology: relevance for mechanistic studies of anaesthesia, Br J Anaesth 72, 506–8 (1994).
R. Lydic, Baghdoyan H.A., Cholinergic contribution to the control of consciousness, Anesthesia: Biologic Foundations. Edited by Yaksh TLeal. Philadelphia, Lippincott-Raven, 1997, pp 433–50
J.C. Keifer, Baghdoyan HA, Becker L, Lydic R, Halothane decreases pontine acethylcholine release and increases EEG spindles, Neuroreport 5, 577–80 (1995).
M.T. Alkire, Haler R.J, Shah N.K, Anderson C.T, Positron emission tomography study of regional cerebral metabolism in humans during isoflurane anesthesia, Anesthesiology 86, 549–57 (1997).
M.T. Alkire, Pomfrett C.J, Haier R.J, Gianzero M.V, Chan C.M, Jacobsen B.P, Functional brain imaging during anesthesia in humans: effects of halothane on global and regional cerebral glucose metabolism, Anesthesiology 90, 701–9 (1999).
L.J. Adler, Gyulai F.E, Diehl D.J, Mintum M.A, Winter P.M, Firestone L.L, Regional brain activity changes associated with fentanyl analgesia elucidated by positron emission tomography, Anesth Analg 84, 120–6 (1997).
CR. Ries, Puil E, Mechanism of anesthesia revealed by shunting actions of isoflurane on thalamocortical neurons, J Neurophysiol 81, 1795–801 (1999).
D.A. Gusnard, Raichle M.E, Raichle M.E, Searching for a baseline: functional imaging and the resting human brain, Nature Reviews Neuroscience 2, 685–94, (2001).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Fiset, P. (2003). Functional Brain Imaging and Propofol Mechanisms of Action. In: Vuyk, J., Schraag, S. (eds) Advances in Modelling and Clinical Application of Intravenous Anaesthesia. Advances in Experimental Medicine and Biology, vol 523. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9192-8_11
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9192-8_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4830-6
Online ISBN: 978-1-4419-9192-8
eBook Packages: Springer Book Archive