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Basic Pharmacokinetic Principles for Intravenous Anaesthesia

  • Frank H. M. Engbers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 523)

Abstract

The ultimate aim of pharmacological research is to describe the dose-effect relationship of drugs. This relationship is difficult to describe because it is time dependent. A phase difference exists between the moment of administration of the drug and the observed effect. Furthermore, continuous measurement of the effect of a drug is not always possible. If blood concentrations of the drug can be measured then the dose-effect relationship is divided into a dose-concentration relationship (pharmacokinetics) and a concentration-effect relationship (pharmacodynamics).

Keywords

Infusion Rate Blood Concentration Pharmacokinetic Model Central Compartment Intravenous Anaesthesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Frank H. M. Engbers
    • 1
  1. 1.Leiden University Medical CenterDepartment of AnaesthesiologyLeidenNetherlands

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