Basic Pharmacokinetic Principles for Intravenous Anaesthesia
The ultimate aim of pharmacological research is to describe the dose-effect relationship of drugs. This relationship is difficult to describe because it is time dependent. A phase difference exists between the moment of administration of the drug and the observed effect. Furthermore, continuous measurement of the effect of a drug is not always possible. If blood concentrations of the drug can be measured then the dose-effect relationship is divided into a dose-concentration relationship (pharmacokinetics) and a concentration-effect relationship (pharmacodynamics).
KeywordsInfusion Rate Blood Concentration Pharmacokinetic Model Central Compartment Intravenous Anaesthesia
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