Sperm Nuclear DNA Damage in the Human

  • Denny Sakkas
  • Gian Carlo Manicardi
  • Davide Bizzaro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 518)

Abstract

The male partner is now recognized as the single most common contributor to a couple’s reason for infertility, with sperm defects accounting for around 30–50% of cases presenting to infertility clinics (Hull, 1992). A standard semen analysis, in particular the assessment of sperm concentration and motility, should therefore always be viewed as a mandatory test for inclusion in the investigation of the infertile couple (WHO, 1992; WHO,1999). A semen analysis, however, only helps to provide broad diagnostic categories.

Keywords

Toxicity Hydrogen Peroxide Electrophoresis Germinal Hull 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Denny Sakkas
    • 1
  • Gian Carlo Manicardi
    • 2
  • Davide Bizzaro
    • 3
  1. 1.Department of Obstetrics and GynaecologyYale University School of MedicineConnecticutUSA
  2. 2.Department of Animal BiologyUniversity of Modena and Reggio EmiliaItaly
  3. 3.Institute of Biology and GeneticsUniversity of AnconaItaly

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