Sperm Nuclear DNA Damage in the Human

  • Denny Sakkas
  • Gian Carlo Manicardi
  • Davide Bizzaro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 518)


The male partner is now recognized as the single most common contributor to a couple’s reason for infertility, with sperm defects accounting for around 30–50% of cases presenting to infertility clinics (Hull, 1992). A standard semen analysis, in particular the assessment of sperm concentration and motility, should therefore always be viewed as a mandatory test for inclusion in the investigation of the infertile couple (WHO, 1992; WHO,1999). A semen analysis, however, only helps to provide broad diagnostic categories.


Seminiferous Tubule Human Spermatozoon Intracytoplasmic Sperm Injection Semen Parameter Sperm Chromatin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Denny Sakkas
    • 1
  • Gian Carlo Manicardi
    • 2
  • Davide Bizzaro
    • 3
  1. 1.Department of Obstetrics and GynaecologyYale University School of MedicineConnecticutUSA
  2. 2.Department of Animal BiologyUniversity of Modena and Reggio EmiliaItaly
  3. 3.Institute of Biology and GeneticsUniversity of AnconaItaly

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