Abstract
It is clear from many of the chapters in this volume that exposure of males to toxic chemicals or radiation can adversely affect subsequent generations. The endpoints for these adverse effects on progeny outcome have varied from pre-implantation and/or postimplantation death, to malformations, altered behaviour, or cancer. Effects may not be manifested until adulthood. Furthermore, several studies have shown that even “apparently normal” F1 offspring can transmit adverse effects to the F2 generation (Auroux et al., 1988; Hales et al, 1992)
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Hales, B.F., Cyr, D.G. (2003). Study Designs for the Assessment of Male-Mediated Developmental Toxicity. In: Robaire, B., Hales, B.F. (eds) Advances in Male Mediated Developmental Toxicity. Advances in Experimental Medicine and Biology, vol 518. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9190-4_25
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DOI: https://doi.org/10.1007/978-1-4419-9190-4_25
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