Female-specific reproductive toxicites following preconception exposure to xenobiotics
There are only a few testing strategies directed specifically at female reproductive toxicity. (Generoso et al, 1971; Generoso and Cosgove, 1973; Bishop et al., 1997). There are some elegant molecular studies of female germ cell and reproductive biology (Eichenlaub-Ritter, et al., 1988; Albertini, et al., 2001; Hunt et al, 1995) but few, if any, of these investigations involve toxicological perspectives. Future research efforts in female, as well as male, reproductive toxicology would benefit greatly by enhanced integration of knowledge and methodology from molecular developmental and cell biology. In this chapter, I will review some basic reproductive biology, emphasizing differences between females and males, describe tests for female reproductive toxicology used by the National Toxicology Program (NTP) at NIEHS, summarize NTP test data and discuss some of the dogmas of germ cell mutagenesis that have recently been dispelled by these data.
KeywordsPyrene Etoposide Urethane Toxicology Bleomycin
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