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The Genome of Pseudomonas aeruginosa

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Pseudomonas

Abstract

One of the remarkable properties of the common soil organism Pseudomonas aeruginosa is its ability to cause infections in a wide variety of hosts, including insects, plants, and animals 27. In humans, this organism can colonize virtually any mucosal surface and can invade tissues and blood. The infections can be of short duration and superficial, life threatening acute bacteremia, or chronic, spanning many decades, as in patients with cystic fibrosis25, 26, 36. This ability to thrive in what may be arguably the broadest distribution of ecological niches for any bacterial species was expected to be matched by a complex, highly regulated genomic repertoire. Not surprisingly, early estimates of the genomic size suggested a relatively large genome exceeding 6 Mb47. The completion of the sequencing project of the P. aeruginosa PAO1 genome in 200050 and the results from the second P. aeruginosa genome sequencing of the strain PA14 clearly demonstrate that the ecological diversity is indeed reflected in the gene content, with the coding capacity of the P. aeruginosa genomes comparable to that of a simple eukaryote Saccharomyces cerevisiea, at c. 6,000 open reading frames (ORFs).

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Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, 02115, USA

    Bridget R. Kulasekara & Stephen Lory

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  1. Bridget R. Kulasekara
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  2. Stephen Lory
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  1. CSIC, Granada, Spain

    Juan-Luis Ramos

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Kulasekara, B.R., Lory, S. (2004). The Genome of Pseudomonas aeruginosa . In: Ramos, JL. (eds) Pseudomonas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9086-0_2

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  • DOI: https://doi.org/10.1007/978-1-4419-9086-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4788-0

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