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Peroxisomal Disorders and Regulation of Genes pp 335–354Cite as

Plasmalogens, Docosahexaenoic Acid and Neurological Disorders

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 544))

Abstract

Among glycerophospholipids, plasmalogens represent a special class that is characterized by the presence of a long-chain enol ether (vinyl ether) bond at the sn-l position of the glycerol moiety. The levels of ethanolamine plasmalogen in brain tissue depend on the degree of myelination (Horrocks and Sharma, 1982). Thus the concentration of plasmalogens increases rapidly during the intense period of myelination and the ethanolamine glycerophospholipids in myelin include up to 70% plasmalogens. The enol ether-linked aliphatic moieties at the sn-l position in plasmalogens are almost exclusively 16:0, 18:0, and 18:1 and form the corresponding fatty aldehyde upon acid hydrolysis. The sn-2 position in the glycerol moiety of plasmalogens is enriched in arachidonic acid, AA, 20:4 n-6, or docosahexaenoic acid, DHA, 22:6 n-3.

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Authors and Affiliations

  1. Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, 43210, USA

    Akhlaq A. Farooqui & Lloyd A. Horrocks

  2. Department of Anatomy, National University of Singapore, Singapore, 119260

    Wei-Yi Ong

Authors
  1. Akhlaq A. Farooqui
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  2. Wei-Yi Ong
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  3. Lloyd A. Horrocks
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Editors and Affiliations

  1. Ghent University, Ghent, Belgium

    Frank Roels  & Sylvia De Bie  & 

  2. K.U. Leuven, Leuven, Belgium

    Myriam Baes

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© 2003 Springer Science+Business Media New York

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Farooqui, A.A., Ong, WY., Horrocks, L.A. (2003). Plasmalogens, Docosahexaenoic Acid and Neurological Disorders. In: Roels, F., Baes, M., De Bie, S. (eds) Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology, vol 544. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9072-3_45

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  • DOI: https://doi.org/10.1007/978-1-4419-9072-3_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4782-8

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