Metabolic Regulation of Peroxisomal and Mitochondrial Fatty Acid Oxidation
Glucose and fatty acids are the major metabolic fuels for the cell. Cells possess the entire set of genes for carbohydrate and fat metabolism. Depending on fuel levels, fuel induced hormone secretion and cross talk between metabolic pathways, cells choose between glucose and fatty acid breakdown to provide their energy. During fasting large amounts of fatty acids are set free by the adipose tissue, glucagon level rises and fatty acid oxidation is favoured. Fatty acids are broken down in mitochondria and in peroxisomes. Mitochondria can fully degrade fatty acids into acetyl-CoA units (and eventually to C02 and water in the Krebs cycle); peroxisomes can only chain-shorten fatty acids and produce H202 in this process. In this paper, aspects of short term (metabolic) regulation of fatty acid oxidation are discussed.
KeywordsCarbohydrate Lipase Pyruvate NADH Cardiol
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