Dehydroepiandrosterone Induction of the Abcd2 and Abcd3 Genes encoding peroxisomal ABC Transporters

Implications for X-linked adrenoleukodystrophy
  • Fabien Gueugnon
  • Fabrice Lambert
  • Catherine Gondcaille
  • Stephane Fourcade
  • Jerome Bellenger
  • Francoise Cadepond
  • Martine El Etr
  • Stephane Savary
  • Maurice Bugaut
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 544)

Abstract

Dehydroepiandrosterone (DHEA) is a peroxisome proliferator known to increase the expression of the genes encoding the peroxisomal ß-oxidation enzymes in rodents. Using RT-PCR, we analysed the expression of the Abcd2 and Abcd3 genes encoding the peroxisomal ABC transporters ALDRP (ALD related protein) and PMP70 (70 kDa peroxisomal membrane protein) in primary cultures of rats hepatocytes treated with sulfated DHEA. We observed a time (12-72h) and dose (125-500μM) dependent increase in the expression of both genes.

Keywords

DHEA Dehydroepiandrosterone Adrenoleukodystrophy Sulfated DHEA 

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Fabien Gueugnon
    • 1
  • Fabrice Lambert
    • 1
  • Catherine Gondcaille
    • 1
  • Stephane Fourcade
    • 1
  • Jerome Bellenger
    • 2
  • Francoise Cadepond
    • 3
  • Martine El Etr
    • 3
  • Stephane Savary
    • 1
  • Maurice Bugaut
    • 1
  1. 1.Laboratory of Molecular and Cellular Biology, Faculty of Sciences GabrielUniversity of BurgundyDijonFrance
  2. 2.UPRES Lipids and NutritionUniversity of BurgundyDijonFrance
  3. 3.Le Kremlin-BicêtreFrance

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