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Colitis in Childhood

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Pathology of Pediatric Gastrointestinal and Liver Disease

Abstract

The differential diagnosis of colitis in pediatrics encompasses numerous entities. Many are infectious, of acute onset, follow a self-limited course, and are diagnosed with a combination of clinical features and microbiologic cultures. These are rarely seen by the pathologist unless complications develop or they are in the setting of immunodeficiency. Endoscopic biopsy and surgical specimens are obtained most frequently in those entities without an identifiable pathogen or which follow a prolonged clinical course, when the possibility of chronic inflammatory bowel disease is raised or in the course of therapy and management of complications. The evaluation of specimens in these settings is essential to confirm the presence of an inflammatory disorder, to establish a diagnosis, to distinguish acute, selflimited disease from chronic processes, to determine the extent of disease, and to assess the efficacy of therapy.

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References

  1. Lowichik A, Weinberg AG. A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract. Mod Pathol 1996;9:110–114.

    PubMed  CAS  Google Scholar 

  2. Pascal RR, Grämlich TL, Parker KM, Gansler TS. Geographic variations in eosinophil concentration in normal colonic mucosa. Mod Pathol 1997;10(4):363–365.

    PubMed  CAS  Google Scholar 

  3. Withers GD, Scott RB. Drug-induced bowel injury. In: Walker WA, et al, eds. Pediatric Gastrointestinal Disease. Hamilton, Ontario: BC Decker,-2000:788–795.

    Google Scholar 

  4. Zwas FR, Cirillo NW, el-Serag HB, Eisen RN. Colonie mucosal abnormalities associated with oral sodium phosphate solution. Gastrointest Endosc. 1996;43(5):463–466.

    Article  PubMed  CAS  Google Scholar 

  5. Leriche M, Devroede G, Sanchez G, Rossano J. Changes in the rectal mucosa induced by hypertonic enemas. Dis Colon Rectum. 1978;21(4):227–236.

    Article  PubMed  CAS  Google Scholar 

  6. Jonas G, Mahoney A, Murray J, Gertler S. Chemical colitis due to endoscope cleaning solutions: a mimic of pseudomembranous colitis. Gastroenterology. 1988;95(5):1403–1408.

    PubMed  CAS  Google Scholar 

  7. Sicherer SH. Food protein-induced enterocolitis syndrome: clinical perspectives. J Pediatr Gastroenterol Nutr. 2000;30(Suppl): S45–S49.

    Article  PubMed  Google Scholar 

  8. Lake AM. Food-induced eosinophilic proctocolitis. J Pediatr Gastroenterol Nutr. 2000; 30(Suppl):S58–S60.

    Article  PubMed  Google Scholar 

  9. Chang JW, Wu TC, Wang KS, Huang IF, Huang B, Yu IT. Colon mucosal pathology in infants under three months of age with diarrhea disorders, J Pediatr Gastroenterol Nutr. 2002;35(3):387–390.

    Article  PubMed  Google Scholar 

  10. Odze RD, Bines J, Leichtner AM, Goldman H, Antonioli DA. Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study. Hum Pathol. 1993;24(6):668–674.

    Article  PubMed  CAS  Google Scholar 

  11. Machida HM, Catto Smith AG, Gall DG, Trevenen C, Scott RB. Allergic colitis in infancy: clinical and pathologic aspects. J Pediatr Gastroenterol Nutr. 1994;19(1):22–26.

    Article  PubMed  CAS  Google Scholar 

  12. Gottrand F, Erkan T, Turck D, Farriaux JP, Dejobert Y, Lecomte-Houcke M. Food-induced bleeding from lymphonodular hyperplasia of the colon. Am J Dis Child. 1993; 147(8):821–823.

    PubMed  CAS  Google Scholar 

  13. Cuffari C, Oligny L, Seidman EG. Dientamoeba fragilis masquerading as allergic colitis. J Pediatr Gastroenterol Nutr. 1998; 26(1):16–20.

    Article  PubMed  CAS  Google Scholar 

  14. Lowichik A, Weinberg AG. Eosinophilic infiltration of the enteric neural plexuses in Hirschsprung’s disease. Pediatr Pathol Lab Med. 1997;17(6):885–891.

    Article  PubMed  CAS  Google Scholar 

  15. Andiran F, Dayi S. Hirschsprung’s disease or allergic colitis or necrotising enterocolitis? Pediatr Radiol. 2000;30(12):881.

    Article  PubMed  CAS  Google Scholar 

  16. Bloom DA, Buonomo C, Fishman SJ, Furuta G, Nurko S. Allergic colitis: a mimic of Hirschsprung disease. Pediatr Radiol. 1999;29(1):37–41.

    Article  PubMed  CAS  Google Scholar 

  17. Ng S. Necrotizing enterocolitis in the full-term neonate. J Paediatr Child Health. 2001;37(1):1–4.

    Article  PubMed  CAS  Google Scholar 

  18. Israel EJ, Morera C. Necrotizing enterocolitis. In: Walker WA, et al, eds. Pediatric Gastrointestinal Disease. Hamilton, Ontario: BC Decker; 2000:665–676.

    Google Scholar 

  19. Caplan MS, Jilling T. New concepts in necrotizing enterocolitis. Curr Opin Pediatr. 2001;13(2):111–115.

    Article  PubMed  CAS  Google Scholar 

  20. Reber KM, Nankervis CA, Nowicki PT. Newborn intestinal circulation. Physiology and pathophysiology. Clin Perinatol. 2002;29(1):23–39.

    Article  PubMed  Google Scholar 

  21. Albanese CT, Rowe MI. Necrotizing enterocolitis. In: O’Neill JA, et al, eds. Pediatric Surgery. St. Louis, MO: Mosby; 1998: 1297–1330.

    Google Scholar 

  22. Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg. 1978;187(1):1–7.

    Article  PubMed  CAS  Google Scholar 

  23. Dahms BB. The gastrointestinal tract. In: JT Stocker, Dehner LP, eds. Pediatric Pathology. Philadelphia, PA: Lippincott Williams and Wilkins; 2001:631–704.

    Google Scholar 

  24. Kocoshis SA. Other diseases of the small intestine and colon. In: Wyllie R, Hyams J, eds. Pediatric Gastrointestinal Disease. Philadelphia, PA: WB Saunders; 1999:532–550.

    Google Scholar 

  25. Moja P, Quesnel A, Resseguier V, et al. Is there IgA from gut mucosal origin in the serum of children with Henoch-Schonlein purpura? Clin Immunol Immunopathol. 1998;86(3):290–297.

    Article  PubMed  CAS  Google Scholar 

  26. Esaki M, Matsumoto T, Nakamura S, et al. GI involvement in Henoch-Schonlein purpura. Gastrointest Endosc. 2002;56(6): 920–923.

    Article  PubMed  Google Scholar 

  27. Choong CK, Beasley SW. Intra-abdominal manifestations of Henoch-Schonlein purpura. J Paediatr Child Health. 1998;34(5): 405–409.

    Article  PubMed  CAS  Google Scholar 

  28. Bissonnette R, Dansereau A, D’Amico P, Pateneaude JV, Paradis J. Perforation of large and small bowel in Henoch-Schonlein purpura. Int J Dermatol. 1997;36(5):361–363.

    Article  PubMed  CAS  Google Scholar 

  29. Chesler L, Hwang L, Patton W, Heyman MB. Henoch-Schonlein purpura with severe jejunitis and minimal skin lesions. J Pediatr Gastroenterol Nutr. 2000;30(1):92–95.

    Article  PubMed  CAS  Google Scholar 

  30. Novak J, Ottlakan A, Toth K. Colonie biopsy in Henoch-Schonlein purpura. Gastrointest Endosc. 1995;41(5):519.

    Article  PubMed  CAS  Google Scholar 

  31. Teitelbaum DH, Coran AG. Enterocolitis. Semin Pediatr Surg. 1998;7(3):162–169.

    PubMed  CAS  Google Scholar 

  32. Coran AG, Teitelbaum DH. Recent advances in the management of Hirschsprung’s disease. Am J Surg. 2000;180(5):382–387.

    Article  PubMed  CAS  Google Scholar 

  33. Teitelbaum DH, Qualman SJ, Caniano DA. Hirschsprung’s disease. Identification of risk factors for enterocolitis. Ann Surg. 1988;207(3):240–244.

    Article  PubMed  CAS  Google Scholar 

  34. Rescorla FJ, Morrison AM, Engles D, West KW, Grosfeld JL. Hirschsprung’s disease. Evaluation of mortality and long-term function in 260 cases. Arch Surg. 1992;127(8): 934–941; discussion 941-942.

    Article  PubMed  CAS  Google Scholar 

  35. Caniano DA, Teitelbaum DH, Qualman SJ. Management of Hirschsprung’s disease in children with trisomy 21. Am J Surg. 1990; 159(4):402–404.

    Article  PubMed  CAS  Google Scholar 

  36. Teitelbaum DH, Caniano DA, Qualman SJ. The pathophysiology of Hirschsprung’s-associated enterocolitis: importance of histologie correlates. J Pediatr Surg. 1989;24(12):1271–1277.

    Article  PubMed  CAS  Google Scholar 

  37. Wilson-Storey D, Scobie WG. Impaired gastrointestinal mucosal defense in Hirschsprung’s disease: a clue to the pathogenesis of enterocolitis? J Pediatr Surg. 1989;24(5):462–464.

    Article  PubMed  CAS  Google Scholar 

  38. Pozo F, Soler P, Ladron de Guevara C. Pseudomembranous colitis associated with Hirschsprung’s disease. Clin Infect Dis. 1994;19(6):1160–1161.

    Article  PubMed  CAS  Google Scholar 

  39. Hsieh WS, Yang PH, Huang CS, Wang CR. Hirschsprung’s disease presenting with diffuse intestinal pneumatosis in a neonate. Acta Paediatr Taiwan. 2000;41(6):336–338.

    PubMed  CAS  Google Scholar 

  40. Schumacher G. First attack of inflammatory bowel disease and infectious colitis. A clinical, histological and microbiological study with special reference to early diagnosis. Scand J Gastroenterol Suppl. 1993;198:1–24.

    PubMed  CAS  Google Scholar 

  41. Caumes E, Ehya N, Nguyen J, Bricaire F. Typhoid and paratyphoid fever: a 10-year retrospective study of 41 cases in a Parisian hospital. J Travel Med. 2001;8(6):293–297.

    Article  PubMed  CAS  Google Scholar 

  42. Kraus MD, Amatya B, Kimula Y. Histopathology of typhoid enteritis: morphologic and immunophenotypic findings. Mod Pathol. 1999;12(10):949–955.

    PubMed  CAS  Google Scholar 

  43. Kelly JK, Owen DA. Bacterial diarrheas and dysenteries. In: Connor DH, et al, eds. Pathology of Infectious Diseases. Stamford, CT: Appleton and Lange; 1997:421–430.

    Google Scholar 

  44. Narain JP, Lofgren JP. Epidemic of restaurant-associated illness due to Salmonella newport. South Med J. 1989;82(7):837–840.

    Article  PubMed  CAS  Google Scholar 

  45. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-2001. A 17-year-old girl with worsening abdominal pain, fever, and diarrhea after a recent cesarean section. N Engl J Med. 2001;344(21):1622–1627.

    Article  Google Scholar 

  46. Sachdev HP, Chadha V, Malhotra V, Verghese A, Puri RK. Rectal histopathology in endemic Shigella and Salmonella diarrhea. J Pediatr Gastroenterol Nutr. 1993;16(1):33–38.

    Article  PubMed  CAS  Google Scholar 

  47. Schofield PF, Mandai BK, Ironside AG. Toxic dilatation of the colon in Salmonella colitis and inflammatory bowel disease. Br J Surg. 1979;66(1):5–8.

    Article  PubMed  CAS  Google Scholar 

  48. Bhatt R, Rickett A. Salmonella colitis: a mimic of Hirschsprung disease. Pediatr Radiol. 2000;30(6):431–432.

    Article  PubMed  CAS  Google Scholar 

  49. Gross E, Engelhard D, Katz S. Large bowel obstruction: an unusual presentation of salmonella enterocolitis in infancy. Pediatr Surg Int. 2000;16(7):525–526.

    Article  PubMed  CAS  Google Scholar 

  50. Speelman P, Kabir I, Islam M. Distribution and spread of colonic lesions in shigellosis: a colonoscopic study. J Infect Dis. 1984; 150(6):899–903.

    Article  PubMed  CAS  Google Scholar 

  51. Butler T, Dunn D, Dahms B, Islam M. Causes of death and the histopathologic findings in fatal shigellosis. Pediatr Infect Dis J. 1989;8(11):767–772.

    Article  PubMed  CAS  Google Scholar 

  52. Anand BS, Malhotra V, Bhattacharya SK, et al. Rectal histology in acute bacillary dysentery. Gastroenterology. 1986;90(3):654–660.

    PubMed  CAS  Google Scholar 

  53. Price AB, Jewkes J, Sanderson PJ. Acute diarrhoea: Campylobacter colitis and the role of rectal biopsy. J Clin Pathol. 1979;32(10):990–997.

    Article  PubMed  CAS  Google Scholar 

  54. Svenungsson B, Lagergren A, Ekwall E, Evengard B, Hedlund KO, Karnell A, et al. Enteropathogens in adult patients with diarrhea and healthy control subjects: a 1-year prospective study in a Swedish clinic for infectious diseases. Clin Infect Dis. 2000; 30(5):770–778.

    Article  PubMed  CAS  Google Scholar 

  55. Levine MM. Escherichia coli that cause diarrhea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohemorrhagic, and enteroadherent. J Infect Dis. 1987;155(3):377–389.

    Article  PubMed  CAS  Google Scholar 

  56. Griffin PM, Ostroff SM, Tauxe RV, et al. Illnesses associated with Escherichia coli 157:H7 infections. A broad clinical spectrum. Ann Intern. Med 1988;109(9):705–712.

    PubMed  CAS  Google Scholar 

  57. Ostroff SM, Kobayashi JM, Lewis JH. Infections with Escherichia coli O157:H7 in Washington State. The first year of statewide disease surveillance. JAMA. 1989;262(3): 355-359.

    Article  PubMed  CAS  Google Scholar 

  58. Boyce TG, Swerdlow DL, Griffin PM. Escherichia coli O157:H7 and the hemolytic-uremic syndrome. N Engl J Med. 1995;333(6): 364–368.

    Article  PubMed  CAS  Google Scholar 

  59. Pai CH, Gordon R, Sims HV, Bryan LE. Sporadic cases of hemorrhagic colitis associated with Escherichia coli 0157:H7. Clinical, epidemiologic, and bacteriologic features. Ann Intern Med. 1984;101(6):738–742.

    PubMed  CAS  Google Scholar 

  60. Griffin PM. E.coli O157:H7 and other enterohemorrhagic E. coli. In: Blaser MJ, Smith PD, Ravdin JI, eds. Infections of the Gastrointestinal Tract. New York; Raven Press,-1995:739–761.

    Google Scholar 

  61. Le Saux N, Spika JS, Friesen B, et al. Ground beef consumption in noncommercial settings is a risk factor for sporadic Escherichia coli O157:H7 infection in Canada. J Infect Dis. 1993; 167(2):500–502.

    Article  PubMed  Google Scholar 

  62. Wells JG, Davis BR, Wachsmuth IK, et al. Laboratory investigation of hemorrhagic colitis outbreaks associated with a rare Escherichia coli serotype. J Clin Microbiol. 1983;18(3):512–520.

    PubMed  CAS  Google Scholar 

  63. Bell BP, Goldoft M, Griffin PM, et al. A multistate outbreak of Escherichia coli O157:H7-associated bloody diarrhea and hemolytic uremic syndrome from hamburgers. The Washington experience. JAMA. 1994;272(17):1349–1353.

    Article  PubMed  CAS  Google Scholar 

  64. Spika JS, Parsons JE, Nordenberg D, Wells JG, Gunn RA, Blake PA. Hemolytic uremic syndrome and diarrhea associated with Escherichia coli 0157:H7 in a day care center. J Pediatr. 1986;109(2):287–291.

    Article  PubMed  CAS  Google Scholar 

  65. Cimolai N, Carter JE, Morrison BJ, Anderson JD. Risk factors for the progression of Escherichia coli O157:H7 enteritis to hemolytic-uremic syndrome. J Pediatr. 1990;116(4):589–592.

    Article  PubMed  CAS  Google Scholar 

  66. Ashkenazi S, May L, LaRocco M, Lopez EL, Cleary TG. The effect of postnatal age on the adherence of enterohemorrhagic Escherichia coli to rabbit intestinal cells. Pediatr Res. 1991; 29(1):14–19.

    Article  PubMed  CAS  Google Scholar 

  67. Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002; 347(8):589–600.

    Article  PubMed  CAS  Google Scholar 

  68. Carter AO, Borczyk AA, Carlson JA, et al. A severe outbreak of Escherichia coli O157:H7- associated hemorrhagic colitis in a nursing home. N Engl J Med. 1987;317(24):1496–1500.

    Article  PubMed  CAS  Google Scholar 

  69. Salmon RL, Farrell ID, Hutchison JG, et al. A christening party outbreak of haemorrhagic colitis and haemolytic uraemic syndrome associated with Escherichia coli O 157.H7. Epidemiol Infect. 1989;103(2):249–254.

    Article  PubMed  CAS  Google Scholar 

  70. Tarr PI, Clausen CR, Christie DL. Bacterial and protozoal gastroenteritis. N Engl J Med. 1992;326(7):489.

    Article  PubMed  CAS  Google Scholar 

  71. Griffin PM, Olmstead LC, Petras RE. Escherichia coli 0157:H7- associated colitis. A clinical and histological study of 11 cases. Gastwenterology. 1990;99(1):142–149.

    CAS  Google Scholar 

  72. March SB, Ratnam S. Sorbitol-MacConkey medium for detection of Escherichia coli 0157:H7 associated with hemorrhagic colitis. J Clin Microbiol. 1986;23(5):869–872.

    PubMed  CAS  Google Scholar 

  73. Murray KF, Patterson K. Escherichia coli O157:H7-induced hemolytic-uremic syndrome: histopathologic changes in the colon over time. Pediatr Dev Pathol. 2000;3(3):232–239.

    Article  PubMed  CAS  Google Scholar 

  74. Tarr PI, Neill MA, Clausen CR, Watkins SL, Christie DL, Hick-man RO. Escherichia coli O157:H7 and the hemolytic uremic syndrome: importance of early cultures in establishing the etiology. J Infect Dis. 1990;162(2):553–556.

    Article  PubMed  CAS  Google Scholar 

  75. Brandt ML, O’Regan S, Rousseau E, Yazbeck S. Surgical complications of the hemolytic-uremic syndrome. J Pediatr Surg. 1990;25(11):1109–1112.

    Article  PubMed  CAS  Google Scholar 

  76. Lamps LW, Madhusudhan KT, Greenson JK, et al. The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study. Am J Surg Pathol. 2001;25(4):508–515.

    Article  PubMed  CAS  Google Scholar 

  77. Abdel-Haq NM, Asmar BI, Abuhammour WM, Brown WJ. Yersinia enterocolitica infection in children. Pediatr Infect Dis J. 2000;19(10):954–958.

    Article  PubMed  CAS  Google Scholar 

  78. Hansen MG, Pearl G, Levy M. Intussusception due to Yersinia enterocolitica enterocolitis in a patient with beta-thalassemia. Arch Pathol Lab Med. 2001,125(11): 1486–1488.

    PubMed  CAS  Google Scholar 

  79. Press N, Fyfe M, Bowie W, Kelly M. Clinical and microbiological follow-up of an outbreak of Yersinia pseudotuberculosis serotype Ib. Scand J Infect Dis. 2001;33(7):523–526.

    Article  PubMed  CAS  Google Scholar 

  80. Kobayashi Y, Honda M, Yoshikawa N, Ito H. Acute tubulointerstitial nephritis in 21 Japanese children. Clin Nephrol. 2000;54(3):191–197.

    PubMed  CAS  Google Scholar 

  81. Uchiyama T, Kato H. The pathogenesis of Kawasaki disease and superantigens. Jpn J Infect Dis. 1999;52(4):141–145.

    PubMed  CAS  Google Scholar 

  82. Johnson S, Clabots CR, Linn FV, Olson MM, Peterson LR, Gerding DN. Nosocomial Clostridium difficile colonisation and disease. Lancet. 1990;336(8707):97–100.

    Article  PubMed  CAS  Google Scholar 

  83. Johnson S, Homann SR, Bettin KM, et al. Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin or metronidazole. A randomized, placebo-controlled trial. Ann Intern Med. 1992;117(4):297–302.

    PubMed  CAS  Google Scholar 

  84. Hyams JS, McLaughlin JC. Lack of relationship between Clostridium difficile toxin and inflammatory bowel disease in children. J Clin Gastroenterol. 1985;7(5):387–390.

    Article  PubMed  CAS  Google Scholar 

  85. Meyers S, Mayer L, Bottone E, Desmond E, Janowitz HD. Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease. Gastwenterology. 1981; 80(4):697-70.

    Google Scholar 

  86. Trnka YM, LaMont JT. Association of Clostridium difficile toxin with symptomatic relapse of chronic inflammatory bowel disease. Gastwenterology. 1981;80(4):693–696.

    CAS  Google Scholar 

  87. Brearly S, Armstrong GR, Nairn R, et al. Pseudomembranous colitis: a lethal complication of Hirschsprung’s disease unrelated to antibiotic usage. J Pediatr Surg. 1987;22(3):257–259.

    Article  PubMed  CAS  Google Scholar 

  88. Peach SL, Borriello SP, Gaya H, Barclay FE, Welch AR. Asymptomatic carriage of Clostridium difficile in patients with cystic fibrosis. J Clin Pathol. 1986;39(9):1013–1018.

    Article  PubMed  CAS  Google Scholar 

  89. Rampling A, Warren RE, Bevan PC, Hoggarth CE, Swirsky D, Hayhoe FG. Clostridium difficile in haematological malignancy. J Clin Pathol. 1985;38(4):445–451.

    Article  PubMed  CAS  Google Scholar 

  90. Thomas DF, Fernie DS, Bayston R, Spitz L, Nixon HH. Enterocolitis in Hirschsprung’s disease: a controlled study of the etiologic role of Clostridium difficile, J Pediatr Surg. 1986;21(1):22–25.

    Article  PubMed  CAS  Google Scholar 

  91. De Girolami PC, Hanff PA, Eichelberger K, et al. Multicenter evaluation of a new enzyme immunoassay for detection of Clostridium difficile enterotoxin A. J Clin Microbiol. 1992;30(5):1085–1088.

    PubMed  Google Scholar 

  92. Doern GV, Coughlin RT, Wu L. Laboratory diagnosis of Clostridium difficile-associated gastrointestinal disease: comparison of a monoclonal antibody enzyme immunoassay for toxins A and B with a monoclonal antibody enzyme immunoassay for toxin A only and two cytotoxicity assays. J Clin Microbiol. 1992;30(8):2042–2046.

    PubMed  CAS  Google Scholar 

  93. Baldwin A, Kingman H, Darville M, et al. Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant. 2000; 26(12):1333–1338.

    Article  PubMed  CAS  Google Scholar 

  94. Berrebi D, Ferkdadji L, Delagausie P, Aigrain Y, Peuchmaur M. [Adenovirus and intranuclear inclusions in the appendix in children with acute intussusception]. Ann Pathol. 1997; 17(2):89–93.

    PubMed  CAS  Google Scholar 

  95. Yunis EJ, Atchison RW, Michaels RH, DeCicco FA. Adenovirus and ileocecal intussusception. Lab Invest. 1975;33(4):347–351.

    PubMed  CAS  Google Scholar 

  96. Toogood GJ, Gillespie PH, Gujral S, et al. Cytomegalovirus infection and colonic perforation in renal transplant patients. Transplint. 1996;9(3):248–251.

    Article  CAS  Google Scholar 

  97. Einsele H, Ehninger G, Hebart H, et al. Incidence of local CMV infection and acute intestinal GVHD in marrow transplant recipients with severe diarrhoea. Bone Marrow Transplant. 1994; 14(6):955–963.

    PubMed  CAS  Google Scholar 

  98. Pfau, P, Kochman ML, Furth EE, Lichtenstein GR. Cytomegalovirus colitis complicating ulcerative colitis in the steroid-naive patient. Am J Gastroenterol. 2001;96(3):895–899.

    Article  PubMed  CAS  Google Scholar 

  99. Cottone M, Pietrosi G, Martorana G, et al. Prevalence of Cytomegalovirus infection in severe refractory ulcerative and Crohn’s colitis. Am J Gastroenterol. 2001;96(3):773–775.

    Article  PubMed  CAS  Google Scholar 

  100. Fournier V, Gallet S, Rebaud P, Bouvier R, Dutruge J, [Ulceronecrotizing enterocolitis: the role of Cytomegalovirus. Apropos of a case]. Pediatric. 1989;44(3):189–192.

    CAS  Google Scholar 

  101. Quiros-Tejeira RE, Ament ME, Rivera-Penera T, Cortina G, Vargas JH. Cytomegalovirus enterocolitis in an immunocompetent infant host: another cause of treatable intractable diarrhea in infancy, J Pediatr Gastroenterol Nutr. 1999;29(1):86–90.

    Article  PubMed  CAS  Google Scholar 

  102. Dimmick JE, Bove KE. Cytomegalovirus infection of the bowel in infancy: pathogenetic and diagnostic significance. Pediatr Pathol. 1984;2(1):95–102.

    Article  PubMed  CAS  Google Scholar 

  103. Yost J. Amebiasis. Pediatr Rev. 2002;23(8):293–294.

    Article  PubMed  Google Scholar 

  104. Katz DE, Taylor DN. Parasitic infections of the gastrointestinal tract. Gastroenterol Clin North Am. 2001;30(3):797–815.

    Article  PubMed  CAS  Google Scholar 

  105. Lof tus EV Jr, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Crohn’s disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology. 1998;114(6):1161–1168.

    Article  PubMed  Google Scholar 

  106. Mourn B, Vatn MH, Ekbom A, Aadland E, Fausa O, Lygren I, et al. Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand J Gastroenterol, 1996;31(4):362–366.

    Article  Google Scholar 

  107. Mourn B, Vatn MH, Ekbom A, Aadland E, Fausa O, Lygren I, et al. Incidence of Crohn’s disease in four counties in southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand J Gastroenterol, 1996;31(4):355–361.

    Article  Google Scholar 

  108. Stowe SP, Redmond SR, Stormont JM, Shah AH, Chessin LN, Segal HL, et al. An epidemiologic study of inflammatory bowel disease in Rochester, New York. Hospital incidence. Gastroenterology. 1990;98(1):104–110.

    PubMed  CAS  Google Scholar 

  109. Mamula P, Telega GW, Markowitz JE, Brown KA, Russo PA, Piccoli DA, et al. Inflammatory bowel disease in children 5 years of age and younger. Am J Gastroenterol. 2002;97(8):2005–2010.

    Article  PubMed  Google Scholar 

  110. Orholm M, Munkholm P, Langholz E, Nielsen OH, Sorensen IA, Binder V. Familial occurrence of inflammatory bowel disease. N Engl J Med. 1991;324(2):84–88.

    Article  PubMed  CAS  Google Scholar 

  111. Polito JM, Childs B, Mellits ED, Tokayer AZ, Harris ML, Bayless TM. Crohn’s disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology. 1996;111(3):580–586.

    Article  PubMed  Google Scholar 

  112. Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B. Ulcerative colitis and Crohn’s disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut. 1988;29(7):990–996.

    Article  PubMed  CAS  Google Scholar 

  113. Asakura H, Tsuchiya M, Aiso S, et al. Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. Gastroenterology. 1982;82(3):413–418.

    PubMed  CAS  Google Scholar 

  114. Bouma G, Crusius JB, Garcia-Gonzalez MA, et al. Genetic markers in clinically well defined patients with ulcerative colitis (UC). Clin Exp Immunol. 1999;115(2):294–300.

    Article  PubMed  CAS  Google Scholar 

  115. Danze PM, Colombel JF, Jacquot S, et al. Association of HLA class II genes with susceptibility to Crohn’s disease. Gut. 1996;39(1):69–72.

    Article  PubMed  CAS  Google Scholar 

  116. Reinshagen M, Loeliger C, Kuehnl P, et al. HLA class II gene frequencies in Crohn’s disease: a population based analysis in Germany. Gut. 1996;38(4):538–542.

    Article  PubMed  CAS  Google Scholar 

  117. Ahmad T, Armuzzi A, Bunce M, et al. The molecular classification of the clinical manifestations of Crohn’s disease. Gastroenterology. 2002; 122(4):854–866.

    Article  PubMed  CAS  Google Scholar 

  118. Cuthbert AP, Fisher SA, Mirza MM, et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002;122(4):867–874.

    Article  PubMed  CAS  Google Scholar 

  119. Lesage S, Zouali H, Cezard JP, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet. 2002; 70(4):845–857.

    Article  PubMed  CAS  Google Scholar 

  120. Abreu MT, Taylor KD, Lin YC, et al. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn’s disease. Gastroenterology. 2002;123(3):679–688.

    Article  PubMed  CAS  Google Scholar 

  121. Rioux JD, Daly MJ, Silverberg MS, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet. 2001;29(2):223–228.

    Article  PubMed  CAS  Google Scholar 

  122. Elson CO, Cong Y, Brandwein S, et al. Experimental models to study molecular mechanisms underlying intestinal inflammation. Ann NY Acad Sci. 1998;859:85–95.

    Article  PubMed  CAS  Google Scholar 

  123. Rath HC, Schultz M, Freitag R, et al. Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice. Infect Immun. 2001;69(4):2277–2285.

    Article  PubMed  CAS  Google Scholar 

  124. Swidsinski A, Ladhoff A, Pern thaler A, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology. 2002; 122(1):44–54.

    Article  PubMed  Google Scholar 

  125. Polk DB, Hattner JA, Kerner Jr JA. Improved growth and disease activity after intermittent administration of a defined formula diet in children with Crohn’s disease. JPEN J Parenter Enterai Nutr. 1992;16(6):499–504.

    Article  CAS  Google Scholar 

  126. Telander RL. Surgical management of Crohn’s disease in children. Curr Opin Pediatr 1995;7(3):328–334.

    Article  PubMed  CAS  Google Scholar 

  127. Oliva-Hemker M, Fiocchi C. Etiopathogenesis of inflammatory bowel disease: the importance of the pediatric perspective. Inflamm Bowel Dis. 2002;8(2):112–128.

    Article  PubMed  Google Scholar 

  128. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 1998,115(1):182–205.

    Article  PubMed  CAS  Google Scholar 

  129. Garland CF, Lilienfeld AM, Mendeloff AI, et al. Incidence rates of ulcerative colitis and Crohn’s disease in fifteen areas of the United States. Gastroenterology. 1981;81(6):1115–1124.

    PubMed  CAS  Google Scholar 

  130. Hildebrand H, Brydolf M; Holmquist L, Krantz I, Kristiansson B. Incidence and prevalence of inflammatory bowel disease in children in south-western Sweden Ada Paediatr. 1994;83(6):640–645.

    CAS  Google Scholar 

  131. Calkins BM, Lilienfeld AM, Garland CF, Mendeloff AI. Trends in incidence rates of ulcerative colitis and Crohn’s disease. Dig Dis Sci. 1984.;29(10):913–920.

    Article  PubMed  CAS  Google Scholar 

  132. Lenaerts C, Roy CC, Vaillancourt M, Weber AM, Morin CL, Seidman E. High incidence of upper gastrointestinal tract involvement in children with Crohn disease. Pediatrics. 1989;83(5): 777–781.

    PubMed  CAS  Google Scholar 

  133. Hildebrand H, Aronson S, Selvik G. Growth as a parameter of inflammation in Crohn’s disease, using roentgen stereophotogrammetric analysis. Ada Paediatr. 1994;83(10):1070–1075.

    CAS  Google Scholar 

  134. Markowitz J, Daum F, Aiges H, Kahn E, Silverberg M, Fisher SE. Perianal disease in children and adolescents with Crohn’s disease. Gastroenterology. 1984;86(5 Pt l):829–833.

    PubMed  CAS  Google Scholar 

  135. Seidman EG. Recent advances in the diagnosis and treatment of pediatric inflammatory bowel disease. Curr Gastroenterol Rep. 2000;2(3):248–252.

    Article  PubMed  CAS  Google Scholar 

  136. Mamula P, Telega GW, Markowitz JE, et al. Inflammatory bowel disease in children 5 years of age and younger. Am J Gastroenterol. 2002;97(8):2005–2010.

    Article  PubMed  Google Scholar 

  137. D’Haens G, Geboes K, Peeters M, Baert F, Ectors N, Rutgeerts P. Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopie study. Am J Gastroenterol. 1997;92(8):1275–1279.

    PubMed  Google Scholar 

  138. Okawa K, Aoki T, Sano K, Harihara S, Kitano A, Kuroki T. Ulcerative colitis with skip lesions at the mouth of the appendix: a clinical study. Am J Gastroenterol. 1998;93(12):2405–2410.

    Article  PubMed  CAS  Google Scholar 

  139. Matsumoto T, Nakamura S, Shimizu M, Iida M. Significance of appendiceal involvement in patients with ulcerative colitis. Gastrointest Endosc. 2002;55(2):180–185.

    Article  PubMed  Google Scholar 

  140. Kim B, Barnett JL, Kleer CG, Appelman HD. Endoscopie and histological patchiness in treated ulcerative colitis. Am J Gastroenterol. 1999;94(11):3258–3262.

    Article  PubMed  CAS  Google Scholar 

  141. Kleer CG, Appelman HD. Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time. Am J Surg Pathol. 1998;22(8):983–989.

    Article  PubMed  CAS  Google Scholar 

  142. Markowitz J, Kahn E, Grancher K, Hyams J, Treem W, Daum F. Atypical rectosigmoid histology in children with newly diagnosed ulcerative colitis. Am J Gastroenterol. 1993;88(12):2034–2037.

    PubMed  CAS  Google Scholar 

  143. Washington K, Greenson JK, Montgomery E, Shyr Y, Crissinger KD, Polk DB, et al. Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol. 2002;26(11):1441–1449.

    Article  PubMed  Google Scholar 

  144. Gustavsson S, Weiland LH, Kelly KA. Relationship of backwash ileitis to ileal pouchitis after ileal pouch-anal anastomosis. Dis Colon Rectum. 1987;30(1):25–28.

    Article  PubMed  CAS  Google Scholar 

  145. Heuschen UA, Hinz U, Allemeyer EH, et al. Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. Gastroenterology. 2001;120(4):841–847.

    Article  PubMed  CAS  Google Scholar 

  146. Riddell RH. Pathology of idiopathic inflammatory bowel disease. In: Kirsner JB, Shorter RG, eds. Inflammatory Bowel Disease. Baltimore, MD: Williams and Wilkins; 1995:517–554.

    Google Scholar 

  147. Goldenberg B, Mori K, Friedman IH, Shinya H, Buchwald RP. Fused inflammatory polyps simulating carcinoma in ulcerative colitis. Am J Gastroenterol. 1980;73(5):441–444.

    PubMed  CAS  Google Scholar 

  148. Jenkins D, Balsitis M, Gallivan S, et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol. 1997;50(2):93–105.

    Article  PubMed  CAS  Google Scholar 

  149. Geller SA, Cohen A. Arterial inflammatory-cell infiltration in Crohn’s disease. Arch Pathol Lab Med. 1983;107(9):473–475.

    PubMed  CAS  Google Scholar 

  150. Keller KM, Bender SW, Kirchmann H, et al. Diagnostic significance of epithelioid granulomas in Crohn’s disease in children. Multicenter Paediatric Crohn’s Disease Study Group. J Pediatr Gastroenterol Nutr. 1990;10(1):27–32.

    Article  PubMed  CAS  Google Scholar 

  151. Kleer CG, Appelman HD. Surgical pathology of Crohn’s disease. Surg Clin North Am. 2001;81(1):13–30, vii.

    Article  PubMed  CAS  Google Scholar 

  152. Schmitz-Moormann P, Pittner PM, Sangmeister M. Probability of detecting a granuloma in a colorectal biopsy of Crohn’s disease. Pathol Res Pract. 1984; 178(3):227–229.

    Article  PubMed  CAS  Google Scholar 

  153. Shepherd NA. Granulomas in the diagnosis of intestinal Crohn’s disease: a myth exploded? Histopathology. 2002;41(2):166–168.

    Article  PubMed  CAS  Google Scholar 

  154. Schmitz-Moormann P, Schag M. Histology of the lower intestinal tract in Crohn’s disease of children and adolescents. Multicentric Paediatric Crohn’s Disease Study. Pathol Res Pract. 1990;186(4):479–484.

    Article  PubMed  CAS  Google Scholar 

  155. Markowitz J, Kahn E, Daum F. Prognostic significance of epithelioid granulomas found in rectosigmoid biopsies at the initial presentation of pediatric Crohn’s disease. J Pediatr Gastroenterol Nutr. 1989;9(2):182–186.

    Article  PubMed  CAS  Google Scholar 

  156. Pulimood AB, Ramakrishna BS, Kurian G, et al. Endoscopie mucosal biopsies are useful in distinguishing granulomatous colitis due to Crohn’s disease from tuberculosis. Gut. 1999,45(4): 537–541.

    Article  PubMed  CAS  Google Scholar 

  157. El-Maraghi NR, Mair NS. The histopathology of enteric infection with Yersinia pseudotuberculosis. Am J Clin Pathol. 1979;71(6):631–639.

    PubMed  CAS  Google Scholar 

  158. Isaacs D, Wright VM, Shaw DG, Raafat F, Walker-Smith JA. Chronic granulomatous disease mimicking Crohn’s disease. J Pediatr Gastroenterol Nutr. 1985;4(3):498–501.

    Article  PubMed  CAS  Google Scholar 

  159. Schappi MG, Smith W, Goldblatt D, Lindley KJ, Milla PJ. Colitis in chronic granulomatous disease. Arch Dis Child. 2001;84(2):147–151.

    Article  PubMed  CAS  Google Scholar 

  160. Washington K, Greenson JK, Montgomery E, et al. Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol. 2002;26(11):1441–1449.

    Article  PubMed  Google Scholar 

  161. Markowitz J, Kahn E, Grancher K, Hyams J, Treem W, Daum F. Atypical rectosigmoid histology in children with newly diagnosed ulcerative colitis. Am J Gastroenterol. 1993; 88(12):2034–2037.

    PubMed  CAS  Google Scholar 

  162. Geboes K, Dalle I. Influence of treatment on morphological features of mucosal inflammation. Gut. 2002;50(Suppl 3):III37–III42.

    Article  PubMed  Google Scholar 

  163. Gledhill A, Enticott ME, Howe S. Variation in the argyrophil cell population of the rectum in ulcerative colitis and adenocarcinoma. J Pathol. 1986;149(4):287–291.

    Article  PubMed  CAS  Google Scholar 

  164. Wright CL, Riddell RH. Histology of the stomach and duodenum in Crohn’s disease. Am J Surg Pathol. 1998;22(4):383–390.

    Article  PubMed  CAS  Google Scholar 

  165. Valdez R, Appelman HD, Bronner MP, Greenson JK. Diffuse duodenitis associated with ulcerative colitis. Am J Surg Pathol. 2000;24(10):1407–1413.

    Article  PubMed  CAS  Google Scholar 

  166. Tobin JM, Sinha B, Ramani P, Saleh AR, Murphy MS. Upper gastrointestinal mucosal disease in pediatric Crohn disease and ulcerative colitis: a blinded, controlled study. J Pediatr Gastroenterol Nutr. 2001;32(4):443–448.

    Article  PubMed  CAS  Google Scholar 

  167. Abdullah BA, Gupta SK, Croffie JM, et al. The role of esophagogastroduodenoscopy in the initial evaluation of childhood inflammatory bowel disease: a 7-year study. J Pediatr Gastroenterol Nutr. 2002;35(5):636–640.

    Article  PubMed  Google Scholar 

  168. Parente F, Cucino C, Bollani S, et al. Focal gastric inflammatory infiltrates in inflammatory bowel diseases: prevalence, immunohistochemical characteristics, and diagnostic role. Am J Gastroenterol. 2000;95(3):705–711.

    Article  PubMed  CAS  Google Scholar 

  169. Griffiths AM, Sherman PM. Colonoscopic surveillance for cancer in ulcerative colitis: a critical review. J Pediatr Gastroenterol Nutr. 1997;24(2):202–210.

    Article  PubMed  CAS  Google Scholar 

  170. Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323(18):1228–1233.

    Article  PubMed  CAS  Google Scholar 

  171. Markowitz J, McKinley M, Kahn E, et al. Endoscopie screening for dysplasia and mucosal aneuploidy in adolescents and young adults with childhood onset colitis. Am J Gastioenteiol. 1997; 92(11):2001–2006.

    CAS  Google Scholar 

  172. Blackstone MO, Riddell RH, Rogers BH, Levin B. Dysplasiaassociated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy. Gastroenterology. 1981;80(2):366–374.

    PubMed  CAS  Google Scholar 

  173. van Hogezand R., Eichhorn RF, Choudry A, Veenendaal RA, Lamers CB. Malignancies in inflammatory bowel disease: fact or fiction? Scand J Gastioenteiol Suppl 2002 (236):48–53.

    Article  Google Scholar 

  174. Abrahams NA, Halverson A, Fazio VW, Rybicki LA, Goldblum JR. Adenocarcinoma of the small bowel: a study of 37 cases with emphasis on histologic prognostic factors. Dis Colon Rectum. 2002;45(11):1496–1502.

    Article  PubMed  Google Scholar 

  175. Freeman HJ. Tabulation of myeloid, lymphoid and intestinal malignancies in Crohn’s disease. Can J Gastioenteiol. 2002; 16(11):779–784.

    Google Scholar 

  176. Friedman S, Rubin PH, Bodian C, Goldstein E, Harpaz N, Present DH. Screening and surveillance colonoscopy in chronic Crohn’s colitis. Gastroenterology. 2001;120(4):820–826.

    Article  PubMed  CAS  Google Scholar 

  177. Kilgore SP, Sigel JE, Goldblum JR. Hyperplastic-like mucosal change in Crohn’s disease: an unusual form of dysplasia? Mod Pathol. 2000;13(7):797–801.

    Article  PubMed  CAS  Google Scholar 

  178. Fazio VW. Toxic megacolon in ulcerative colitis and Crohn’s colitis. Clin Gastioenteiol. 1980;9(2):389–407.

    CAS  Google Scholar 

  179. Swan NC, Geoghegan JG, O’Donoghue DP, Hyland JM, Sheahan K. Fulminant colitis in inflammatory bowel disease: detailed pathologic and clinical analysis. Dis Colon Rectum. 1998;41(12):1511–1515.

    Article  PubMed  CAS  Google Scholar 

  180. Price AB. Overlap in the spectrum of non-specific inflammatory bowel disease—’colitis indeterminate’. J Clin Pathol. 1978;31(6):567–577.

    Article  PubMed  CAS  Google Scholar 

  181. Shivananda S, Lennard-Jones J, Logan R, et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut. 1996;39(5):690–697.

    Article  PubMed  CAS  Google Scholar 

  182. Lindberg E, Lindquist B, Holmquist L, Hildebrand H. Inflammatory bowel disease in children and adolescents in Sweden, 1984-1995. J Pediatr Gastioenteiol Nutr. 2000;30(3):259–264.

    Article  CAS  Google Scholar 

  183. Meucci G, Bortoli A, Riccioli FA, et al. Frequency and clinical evolution of indeterminate colitis: a retrospective multi-centre study in northern Italy. GSMII (Gruppo di Studio per le Malattie Infiammatorie Intestinali). Eur J Gastioenteiol Hepatol. 1999; 11(8):909–913.

    Article  CAS  Google Scholar 

  184. Wells AD, McMillan I, Price AB, Ritchie JK, Nicholls RJ. Natural history of indeterminate colitis. Br J Surg. 1991;78(2):179–181.

    Article  PubMed  CAS  Google Scholar 

  185. Marcello PW, Schoetz DJ Jr, Roberts PL, et al. Evolutionary changes in the pathologic diagnosis after the ileoanal pouch procedure. Dis Colon Rectum. 1997;40(3):263–269.

    Article  PubMed  CAS  Google Scholar 

  186. Atkinson KG, Owen DA, Wankling G. Restorative proctocolectomy and indeterminate colitis. Am J Surg. 1994; 167(5):516–518.

    Article  PubMed  CAS  Google Scholar 

  187. Koltun WA, Schoetz DJ Jr, Roberts PL, Murray JJ, Coller JA, Veidenheimer MC. Indeterminate colitis predisposes to perineal complications after ileal pouch-anal anastomosis. Dis Colon Rectum. 1991;34(10):857–860.

    Article  PubMed  CAS  Google Scholar 

  188. Yu CS, Pemberton JH, Larson D. Ileal pouch-anal anastomosis in patients with indeterminate colitis: long-term results. Dis Colon Rectum. 2000;43(11):1487–1496.

    Article  PubMed  CAS  Google Scholar 

  189. Rudolph WG, Uthoff SM, McAuliffe TL, Goode ET, Petras RE, Galandiuk S. Indeterminate colitis: the real story. Dis Colon Rectum. 2002,45(11): 1528–1534.

    Article  PubMed  Google Scholar 

  190. Frayha R, Stevens MB, Bayless TM. Destructive monarthritis and granulomatous synovitis as the presenting manifestations of Crohn’s disease. Johns Hopkins Med J. 1975;137(4):151–155.

    PubMed  CAS  Google Scholar 

  191. Lindsley CB, Schaller JG. Arthritis associated with inflammatory bowel disease in children. J Pediatr. 1974;84(1):16–20.

    Article  PubMed  CAS  Google Scholar 

  192. Winesett M. Inflammatory bowel disease in children and adolescents. Pediati Ann. 1997;26(4):227–234.

    CAS  Google Scholar 

  193. Hofley P, Roarty J, McGinnity G, et al. Asymptomatic uveitis in children with chronic inflammatory bowel diseases. J Pediati Gastioenteiol Nutr. 1993;17(4):397–400.

    Article  CAS  Google Scholar 

  194. Gregorio GV, Portmann B, Reid F, et al. Autoimmune hepatitis in childhood: a 20-year experience. Hepatology. 1997;25(3):541–547.

    Article  PubMed  CAS  Google Scholar 

  195. Wee A, Ludwig J. Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts? Ann Intern Med. 1985;102(5):581–587.

    PubMed  CAS  Google Scholar 

  196. Lindstrom CG. ’Collagenous colitis’ with watery diarrhoea—a new entity? Pathol Eur. 1976,11(1):87–89.

    PubMed  CAS  Google Scholar 

  197. Read NW, Krejs GJ, Read MG, Santa Ana CA, Morawski SG, Fordtran JS. Chronic diarrhea of unknown origin. Gastroenterology. 1980;78(2):264–271.

    PubMed  CAS  Google Scholar 

  198. Lazenby AJ, Yardley JH, Giardiello FM, Jessurun J, Bayless TM. Lymphocytic (”microscopic”) colitis: a comparative histopathologic study with particular reference to collagenous colitis. Hum Pathol. 1989;20(1):18–28.

    Article  PubMed  CAS  Google Scholar 

  199. Mahajan L, Wyllie R, Goldblum J. Lymphocytic colitis in a pediatric patient: a possible adverse reaction to carbamazepine. Am J Gastioenteiol. 1997;92(11):2126–2127.

    CAS  Google Scholar 

  200. Deslandres C, Moussavou-Kombilia JB, Russo P, Seidman EG. Steroid-resistant lymphocytic enterocolitis and bronchitis responsive to 6-mercaptopurine in an adolescent. J Pediati Gastioenteiol Nutr. 1997;25(3):341–346.

    Article  CAS  Google Scholar 

  201. Kong SC, Keogh S, Carter MJ, Lobo AJ, Sanders DS. Familial occurrence of microscopic colitis: an opportunity to study the relationship between microscopic colitis and coeliac disease? Scand J Gastioenteiol. 2002;37(11):1344–1345.

    Article  CAS  Google Scholar 

  202. Abdo AA, Zetler PJ, Halparin LS. Familial microscopic colitis. Can J Gastioenteiol 2001;15(5):341–343.

    CAS  Google Scholar 

  203. Fernandez-Banares F, Salas A, Esteve M, Espinos J, Forne M, Viver JM. Collagenous and lymphocytic colitis, evaluation of clinical and histological features, response to treatment, and long-term follow-up. Am J Gastioenteiol. 2003;98(2):340–347.

    Article  Google Scholar 

  204. Baert F, Wouters K, D’Haens G, et al. Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. Gut. 1999;45(3):375–381.

    Article  PubMed  CAS  Google Scholar 

  205. Pardi DS, Ramnath VR, Loftus EV Jr, Tremaine WJ, Sandborn WJ. Lymphocytic colitis: clinical features, treatment, and outcomes. Am J Gastioenteiol. 2002;97(11):2829–2833.

    Article  Google Scholar 

  206. Bohr J, Tysk C, Yang P, Danielsson D, Jarnerot G. Autoantibodies and immunoglobulins in collagenous colitis. Gut. 1996;39(1):73–76.

    Article  PubMed  CAS  Google Scholar 

  207. Giardiello FM, Lazenby AJ, Bayless TM, et al. Lymphocytic (microscopic) colitis. Clinicopathologic study of 18 patients and comparison to collagenous colitis. Dig Dis Sci. 1989;34(11):1730–1738.

    Article  PubMed  CAS  Google Scholar 

  208. Offner FA, Jao RV, Lewin KJ, Havelec L, Weinstein WM. Collagenous colitis: a study of the distribution of morphological abnormalities and their histological detection. Hum Pathol. 1999;30(4):451–457.

    Article  PubMed  CAS  Google Scholar 

  209. Aigner T, Neureiter D, Muller S, Kuspert G, Belke J, Kirchner T. Extracellular matrix composition and gene expression in collagenous colitis. Gastroenterology. 1997; 113(1):136–143.

    Article  PubMed  CAS  Google Scholar 

  210. Muller S, Neureiter D, Stolte M, et al. Tenascin: a sensitive and specific diagnostic marker of minimal collagenous colitis. Virchows Arch. 2001;438(5):435–441.

    Article  PubMed  CAS  Google Scholar 

  211. Gunther U, Schuppan D, Bauer M, et al. Fibrogenesis and fibrolysis in collagenous colitis. Patterns of procollagen types I and IV, matrix-metalloproteinase-1 and-13, and TIMP-1 gene expression. Am J Pathol. 1999;155(2):493–503.

    Article  PubMed  CAS  Google Scholar 

  212. Busuttil A. Collagenous colitis in a child. Am J Dis Child. 1989;143(9):998–1000.

    PubMed  CAS  Google Scholar 

  213. Perisic VN, Kokai G. Diarrhoea caused by collagenous colitis. Arch Dis Child. 1989;64(6):867–869.

    Article  PubMed  CAS  Google Scholar 

  214. Gremse DA, Boudreaux CW, Manci EA. Collagenous colitis in children. Gastroenterology. 1993; 104(3):906–909.

    PubMed  CAS  Google Scholar 

  215. Esselinckx W, Brenard R, Colin JF, Melange M. Juvenile scleroderma and collagenous colitis. The first case. J Rheumatol. 1989;16(6):834–836.

    PubMed  CAS  Google Scholar 

  216. Wolber R, Owen D, Freeman H. Colonic lymphocytosis in patients with celiac sprue. Hum Pathol. 1990;21(11):1092–1096.

    Article  PubMed  CAS  Google Scholar 

  217. Matteoni CA, Goldblum JR, Wang N, Brzezinski A, Achkar E, Soffer EE. Celiac disease is highly prevalent in lymphocytic colitis. J Clin Gastroenterol. 2001;32(3):225–227.

    Article  PubMed  CAS  Google Scholar 

  218. McCashland TM, Donovan JP, Strobach RS, Linder J, Quigley EM. Collagenous enterocolitis: a manifestation of gluten-sensitive enteropathy. J Clin Gastroenterol. 1992;15(1):45–51.

    Article  PubMed  CAS  Google Scholar 

  219. O’Mahony S, Nawroz IM, Ferguson A. Coeliac disease and collagenous colitis. Postgrad Med J. 1990;66(773):238–241.

    Article  PubMed  Google Scholar 

  220. Bavaro MF. Neutropenic enterocolitis. Curr Gastroenterol Rep. 2002;4(4):297–301.

    Article  PubMed  Google Scholar 

  221. Otaibi AA, Barker C, Anderson R, Sigalet DL. Neutropenic enterocolitis (typhlitis) after pediatric bone marrow transplant. J Pediatr Surg. 2002;37(5):770–772.

    Article  PubMed  Google Scholar 

  222. Jain Y, Arya LS, Kataria R. Neutropenic enterocolitis in children with acute lymphoblastic leukemia. Pediatr Hematol Oncol. 2000;17(1):99–103.

    Article  PubMed  CAS  Google Scholar 

  223. Buyukasik Y, Ozcebe OI, Haznedaroglu IC, et al. Neutropenic enterocolitis in adult leukemias. Int J Hematol. 1997;66(1):47–55.

    PubMed  CAS  Google Scholar 

  224. Moir DH, Bale PM. Necropsy findings in childhood leukaemia, emphasizing neutropenic enterocolitis and cerebral calcification. Pathology. 1976;8(3):247–258.

    Article  PubMed  CAS  Google Scholar 

  225. Newbold KM, Lord MG, Baglin TP. Role of clostridial organisms in neutropenic enterocolitis. J Clin Pathol. 1987,40(4):471.

    Article  PubMed  CAS  Google Scholar 

  226. Baerg J, Murphy JJ, Anderson R, Magee JF. Neutropenic enteropathy: a 10-year review. J Pediatr Surg. 1999;34(7):1068–1071.

    Article  PubMed  CAS  Google Scholar 

  227. Edwards CM, George B, Warren B. Diversion colitis—new light through old windows. Histopathology. 1999;34(1):1–5.

    Article  PubMed  CAS  Google Scholar 

  228. Geraghty JM, Talbot IC. Diversion colitis: histological features in the colon and rectum after defunctioning colostomy. Gut. 1991;32(9):1020–1023.

    Article  PubMed  CAS  Google Scholar 

  229. Ordein JJ, Di Lorenzo C, Flores A, Hyman PE. Diversion colitis in children with severe gastrointestinal motility disorders. Am J Gastroenterol. 1992;87(1):88–90.

    PubMed  CAS  Google Scholar 

  230. Haque S, Eisen RN, West AB. The morphologic features of diversion colitis: studies of a pediatric population with no other disease of the intestinal mucosa. Hum Pathol. 1993;24(2):211–219.

    Article  PubMed  CAS  Google Scholar 

  231. Vujanic GM, Dojcinov SD. Diversion colitis in children: an iatrogenic appendix vermiformis? Histopathology. 2000;36(1):41–46.

    Article  PubMed  CAS  Google Scholar 

  232. Grant NJ, Van Kruiningen HJ, Haque S, West AB. Mucosal inflammation in pediatric diversion colitis: a quantitative analysis. J Pediatr Gastroenterol Nutr. 1997;25(3):273–280.

    Article  PubMed  CAS  Google Scholar 

  233. Yeong ML, Bethwaite PB, Prasad J, Isbister WH. Lymphoid follicular hyperplasia—a distinctive feature of diversion colitis. Histopathology. 1991;19(1):55–61.

    Article  PubMed  CAS  Google Scholar 

  234. Warren BF, Shepherd NA, Bartolo DC, Bradfield JW. Pathology of the defunctioned rectum in ulcerative colitis. Gut. 1993;34(4):514–516.

    Article  PubMed  CAS  Google Scholar 

  235. Lasser A, Acosta AE. Colonie neoplasms complicating ureterosigmoidostomy. Cancer. 1975;35(4):1218–1222.

    Article  PubMed  CAS  Google Scholar 

  236. Stewart M, Macrae FA, Williams CB. Neoplasia and ureterosigmoidostomy: a colonoscopy survey. Br J Surg. 1982;69(7):414–416.

    Article  PubMed  CAS  Google Scholar 

  237. Koo HP, Avolio L, Duckett Jr JW. Long-term results of ureterosigmoidostomy in children with bladder exstrophy. J Urol 1996;156(6):2037–2040.

    Article  PubMed  CAS  Google Scholar 

  238. Rivard JY, Bedard A, Dionne L. Colonie neoplasms following ureterosigmoidostomy. J Urol. 1975;113(6):781–786.

    PubMed  CAS  Google Scholar 

  239. Barton JG, Paden MA, Lane M, Postier RG. Comparison of postoperative outcomes in ulcerative colitis and familial polyposis patients after ileoanal pouch operations. Am J Surg. 2001; 182(6):616–620.

    Article  PubMed  CAS  Google Scholar 

  240. Stocchi L, Pemberton JH. Pouch and pouchitis. Gastroenterol Clin North Am. 2001;30(1):223–241.

    Article  PubMed  CAS  Google Scholar 

  241. Patel RT, Bain I, Youngs D, Keighley MR. Cytokine production in pouchitis is similar to that in ulcerative colitis. Dis Colon Rectum. 1995;38(8):831–837.

    Article  PubMed  CAS  Google Scholar 

  242. Lohmuller JL, Pemberton JH, Dozois RR, Ilstrup D, Heerden J. Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis. Ann Surg. 1990;211(5):622–627; discussion 627-629.

    PubMed  CAS  Google Scholar 

  243. Balbir-Gurman A, D. Schapira D, Nahir M. Arthritis related to ileal pouchitis following total proctocolectomy for ulcerative colitis. Semin Arthritis Rheum. 2001;30(4):242–248.

    Article  PubMed  CAS  Google Scholar 

  244. Stallmach A, Schafer F, Hoffmann S, et al. Increased state of activation of CD4 positive T cells and elevated interferon gamma production in pouchitis. Gut. 1998;43(4):499–505.

    Article  PubMed  CAS  Google Scholar 

  245. Bulois, P, Tremaine WJ, Maunoury V, et al. Pouchitis is associated with mucosal imbalance between interleukin-8 and interleukin-10. Inflamm Bowel Dis. 2000;6(3):157–164.

    Article  PubMed  CAS  Google Scholar 

  246. Penna C, Dozois R, Tremaine W, et al. Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. Gut. 1996;38(2):234–239.

    Article  PubMed  CAS  Google Scholar 

  247. Faubion WA Jr, Loftus EV, Sandborn WJ, Freese DK, Perrault J. Pediatric “PSC-IBD”: a descriptive report of associated inflammatory bowel disease among pediatric patients with psc. J Pediatr Gastroenterol Nutr. 2001;33(3):296–300.

    Article  PubMed  Google Scholar 

  248. Goldstein NS, Sanford WW, Bodzin JH. Crohn’s-like complications in patients with ulcerative colitis after total proctocolectomy and ileal pouch-anal anastomosis. Am J Surg Pathol. 1997; 21(11):1343–1353.

    Article  PubMed  CAS  Google Scholar 

  249. Shepherd NA. The pelvic ileal reservoir: pathology and pouchitis. Neth J Med. 1990;37(Suppl 1):S57–S64.

    Google Scholar 

  250. Warren BF, Shepherd NA. The role of pathology in pelvic ileal reservoir surgery. Int J Colorectal Dis. 1992;7(2):68–75.

    Article  PubMed  CAS  Google Scholar 

  251. Heuschen UA, Autschbach F, Allemeyer EH, et al. Long-term follow-up after ileoanal pouch procedure: algorithm for diagnosis, classification, and management of pouchitis. Dis Colon Rectum. 2001;44(4):487–499.

    Article  PubMed  CAS  Google Scholar 

  252. Thompson-Fawcett MW, Marcus V, Redston M, Cohen Z, McLeod RS. Risk of dysplasia in long-term ileal pouches and pouches with chronic pouchitis. Gastroenterology. 2001; 121(2): 275–281.

    Article  PubMed  CAS  Google Scholar 

  253. Negi SS, Chaudhary A, Gondal R. Carcinoma of pelvic pouch following restorative proctocolectomy: Report of a case and review of the literature. Dig Surg. 2003;20(1):63–65.

    Article  PubMed  Google Scholar 

  254. Sanchez-Izquierdo JA, Lumbreras C, Colina F, et al. Severe graft versus host disease following liver transplantation confirmed by PCR-HLA-B sequencing: report of a case and literature review. Hepatogastroenterology. 1996,43(10): 1057–1061.

    PubMed  CAS  Google Scholar 

  255. Orlin JB, Ellis MH. Transfusion-associated graft-versus-host disease. Curr Opin Hematol. 1997;4(6):442–448.

    Article  PubMed  CAS  Google Scholar 

  256. Denianke KS, Frieden IJ, Cowan MJ, Williams ML, McCalmont TH. Cutaneous manifestations of maternal engraftment in patients with severe combined immunodeficiency: a clinicopathologic study. Bone Marrow Transplant. 2001;28(3):227–233.

    Article  PubMed  CAS  Google Scholar 

  257. Snover DC, Weisdorf SA, Vercellotti GM, Rank B, Hutton S, McGlave P. A histopathologic study of gastric and small intestinal graft-versus-host disease following allogeneic bone marrow transplantation. Hum Pathol. 1985;16(4):387–392.

    Article  PubMed  CAS  Google Scholar 

  258. Abramowsky CR, Coccia PF. Bone marrow transplantation in pediatrics. Perspect Pediatr Pathol. 1989; 13:6–43.

    PubMed  CAS  Google Scholar 

  259. McDonald GB, Sullivan KM, Schuffler MD, Shulman HM, Thomas ED. Esophageal abnormalities in chronic graft-versus-host disease in humans. Gastroenterology. 1981;80(5 pt 1):914–921.

    PubMed  CAS  Google Scholar 

  260. Lloyd-Still JD, Beno DW, Kimura RM. Cystic fibrosis colonopathy. Curr Gastroenterol Rep. 1999;1(3):231–237.

    Article  PubMed  CAS  Google Scholar 

  261. Pawel BR, de Chadarevian JP, Franco ME. The pathology of fibrosing colonopathy of cystic fibrosis: a study of 12 cases and review of the literature. Hum Pathol. 1997;28(4):395–399.

    Article  PubMed  CAS  Google Scholar 

  262. Smyth RL. Fibrosing colonopathy in cystic fibrosis. Arch Dis Child. 1996;74(5):464–468.

    Article  PubMed  CAS  Google Scholar 

  263. Gaia E, Sambatoro A, De Giuli P, Angeli A. Adult fibrosing colonopathy associated with mesalazine treatment. Am J Gastroenterol. 2001;96(8):2508–2509.

    Article  PubMed  CAS  Google Scholar 

  264. Waters BL. Cystic fibrosis with fibrosing colonopathy in the absence of pancreatic enzymes. Pediati Dev Pathol. 1998; 1(1):74–78.

    Article  CAS  Google Scholar 

  265. Serban DE, Florescu P, Miu N. Fibrosing colonopathy revealing cystic fibrosis in a neonate before any pancreatic enzyme supplementation. J Pediati Gastroenterol Nutr. 2002; 35(3):356–359.

    Article  Google Scholar 

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Authors
  1. Pierre Russo
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  2. Kurt Brown
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  3. Robert N. Baldassano
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Pierre Russo MD (Associate Professor, Director) & Eduardo D. Ruchelli MD (Assistant Professor) (Associate Professor, Director) &  (Assistant Professor)

  2. Division of Anatomic Pathology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Pierre Russo MD (Associate Professor, Director) (Associate Professor, Director)

  3. Staff Pathologist, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Eduardo D. Ruchelli MD (Assistant Professor) (Assistant Professor)

  4. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    David A. Piccoli MD (Professor, Division Chief) (Professor, Division Chief)

  5. Gastroenterology and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    David A. Piccoli MD (Professor, Division Chief) (Professor, Division Chief)

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Russo, P., Brown, K., Baldassano, R.N. (2004). Colitis in Childhood. In: Russo, P., Ruchelli, E.D., Piccoli, D.A. (eds) Pathology of Pediatric Gastrointestinal and Liver Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9066-2_5

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  • DOI: https://doi.org/10.1007/978-1-4419-9066-2_5

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  • Print ISBN: 978-1-4612-6492-7

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