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Hepatitis and Liver Failure in Infancy and Childhood

  • Chapter
Pathology of Pediatric Gastrointestinal and Liver Disease

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Abstract

Hepatitis in intrauterine and early postnatal life usually has different causes and clinical features than hepatitic processes experienced by older children and adults. Once obstruction has been excluded, neonatal hepatitis is the most common histologic pattern observed in cholestatic infants. The histologic features of neonatal hepatitis and hepatitis in early childhood are often significantly different from those observed in older patients. Because these features are by themselves frequently not diagnostic of any one liver disease, the pathologist must be familiar with all the potential causes and be able to suggest additional testing modalities, such as assays of metabolic enzymes, determination of specific metabolite levels or ultrastructural examina- tion, that may allow for a definitive diagnosis. In older chil- dren, the differential diagnosis of hepatitis overlaps to a greater extent with causes of hepatitis in adult patients. A detailed discussion of those conditions is beyond the scope of this chapter.

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Authors
  1. Eduardo D. Ruchelli
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  2. Elizabeth B. Rand
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  3. Barbara Anne Haber
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Pierre Russo MD (Associate Professor, Director) & Eduardo D. Ruchelli MD (Assistant Professor) (Associate Professor, Director) &  (Assistant Professor)

  2. Division of Anatomic Pathology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Pierre Russo MD (Associate Professor, Director) (Associate Professor, Director)

  3. Staff Pathologist, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Eduardo D. Ruchelli MD (Assistant Professor) (Assistant Professor)

  4. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    David A. Piccoli MD (Professor, Division Chief) (Professor, Division Chief)

  5. Gastroenterology and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    David A. Piccoli MD (Professor, Division Chief) (Professor, Division Chief)

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© 2004 Springer Science+Business Media New York

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Ruchelli, E.D., Rand, E.B., Haber, B.A. (2004). Hepatitis and Liver Failure in Infancy and Childhood. In: Russo, P., Ruchelli, E.D., Piccoli, D.A. (eds) Pathology of Pediatric Gastrointestinal and Liver Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9066-2_11

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  • DOI: https://doi.org/10.1007/978-1-4419-9066-2_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6492-7

  • Online ISBN: 978-1-4419-9066-2

  • eBook Packages: Springer Book Archive

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