Abstract
The smooth muscle cells express diverse isoforms of the molecular motor Type II myosin. Three different genes coding for myosin heavy chains (MyHC) are expressed, namely one smooth-muscle specific (SM-MyHC), and two non-muscle- specific myosin heavy chain (NM-MyHC), NM-MyHCA, and NM-MyHCB, located on chromosomes 16, 22, and 17, respectively1. Different splice variants of the SM-MyHC are generated due to the alternatively spliced mutually exclusive exons 5b and 392, 3. Elimination of exon 5b in a knock-out mouse model demonstrated that a high contractile state depends on the presence of myosin with 5′-inserted heavy chains4.
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Lamounier-Zepter, V., Baltas, L.G., Morano, I. (2003). Distinct Contractile Systems for Electromechanical and Pharmacomechanical Coupling in Smooth Muscle. In: Sugi, H. (eds) Molecular and Cellular Aspects of Muscle Contraction. Advances in Experimental Medicine and Biology, vol 538. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9029-7_39
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DOI: https://doi.org/10.1007/978-1-4419-9029-7_39
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