Abstract
Iron is a major component of the Earth’s crust, but its own chemistry greatly limits its utilization and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration. In fact, iron deprivation threatens cell survival, thus making iron deficiency in humans a public health problem throughout the world and iron supplementation the only therapeutic option. On the other hand, since humans have no means of controlling iron excretion, excess iron, regardless of the route of entry, accumulates in parenchymal organs and threatens cell viability. In fact, a number of disease states are pathogenetically linked to excess body iron stores and iron removal therapy is an effective life-saving strategy in such circumstances.
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Pietrangelo, A. (2003). Iron transporter ferroportin FPN1. In: Bröer, S., Wagner, C.A. (eds) Membrane Transporter Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9023-5_8
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DOI: https://doi.org/10.1007/978-1-4419-9023-5_8
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