Understanding the Relationship between Carcinogen-Induced DNA Adduct Levels in Distal and Proximal Regions of the Colon
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A number of studies document strong epidemiological and clinical links between diet and colon cancer incidence. In particular, a corn oil-supplemented diet (rich in n-6 polyunsaturated fatty acids) has been shown to be less protective against colon tumorigenesis (Haenszel and Kurihara, 1968; Blot et al., 1975; Bang et al, 1976; Boyle et al. 1985; Chang et al, 1997; Hong et al. 2000) than a fish oil-supplemented diet (rich in n-3 polyunsaturated fatty acids). The mechanisms contributing to this apparent diet effect are still largely unknown, however, and they are currently being investigated (see, for example, Hong et al., 2000).
KeywordsCorrelation Function Proximal Region Parametric Bootstrap Cell Position Adduct Level
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