Fitting a Mathematical Model to Biological Data: Intracellular Trafficking in Niemann-Pick C Disease

  • Meryl E. Wastney
  • Peter G. Pentchev
  • Edward B. Neufeld
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 537)


Mathematical models are powerful and heuristic aids for investigating complex systems. Once a model has been developed, it encompasses a large body of knowledge, and it can be used to make predictions about how a system would react under various conditions. This approach applies whether the system being modeled is physical (e.g., an automobile) or biological.


Intracellular Compartment Intracellular Trafficking Late Endosome Washout Phase Cholesterol Trafficking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Meryl E. Wastney
    • 1
  • Peter G. Pentchev
    • 2
  • Edward B. Neufeld
    • 2
  1. 1.Metabolic Modeling Services, LtdDalesford, HamiltonNew Zealand
  2. 2.National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesda

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