Cornerstones to Shape Modeling for the 21st Century: Introducing the AKA-Glucose Project

  • Ray Boston
  • Darko Stefanovski
  • Peter Moate
  • Oscar Linares
  • Peter Greif
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 537)


For some reason, the start of a new century, as though magically demarcating history, seems to confer the right to reflect on progress as we embrace a ‘new’ period or ‘new’ phase of endeavor. Accordingly, we begin this paper by reviewing what computer-based mathematical modeling in biology (CMMB) has brought us thus far, as we begin the 21st century (or could we say, ‘the third millennium’,). We will decompose the stages of CMMB evolution in the last century into three generations, noting the hallmark accomplishments in each.


Minimal Model SHAPE Modeling Glucose Disposal Database Technology Study Stream 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Ray Boston
    • 1
  • Darko Stefanovski
    • 1
  • Peter Moate
    • 1
  • Oscar Linares
    • 2
  • Peter Greif
    • 3
  1. 1.Biomathematics Unit, New Bolton Center, School of Veterinary MedicineUniversity of PennsylvaniaKennett Square
  2. 2.University of Michigan Geriatrics ClinicAnn Arbor
  3. 3.Laboratory of Computational and Experimental Biology, Division of Cancer Biology and DiagnosisNational Cancer InstituteBethesda

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