The Use of Model-Based Compartmental Analysis to Study Vitamin A Metabolism in a Non-Steady State

  • Michael H. Green
  • Joanne Balmer Green
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 537)


Over the past 20 years, we have collaborated with several laboratories in using mathematical modeling to describe and quantitate whole-body Vitamin A Metabolism in the rat. Steady state models have been developed for animals at different levels of vitamin A status (Green et al., 1985; Lewis et al., 1990; Green and Green, 1994a; Kelley and Green, 1998) and in response to other variables (Kelley et al., 1998; Jang et al., 2000; Kelley et al., 2000). Limited experimental and mathematical evidence (Green and Green, 1994b; Novotny et al., 1995; v Reinersdorff et al., 1998) suggests that there are many similarities in Vitamin A Metabolism between rats and humans. As discussed at the 5th Conference on Mathematical Modeling in Experimental Nutrition in 1994 (Green and Green, 1996), modeling studies have uniquely contributed to current understanding of whole-body Vitamin A Metabolism. In particular, interpretation of kinetic data has revealed previously unrecognized complexities in vitamin A dynamics that facilitate homeostatic control of plasma (and probably tissue) vitamin A levels.


Steady State Model Retinyl Ester TCDD Exposure Plasma Retinol Plasma Tracer 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Michael H. Green
    • 1
  • Joanne Balmer Green
    • 1
  1. 1.Nutrition DepartmentPennsylvania State UniversityUniversity Park

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