The Minimal Model of Glucose Regulation: A Biography

  • Richard N. Bergman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 537)


The life history of the so-called “minimal model” of glucose regulation can be traced back over two decades. During the decades after World War II, the science of cybernet-ics was introduced by Norbert Weiner at MIT (Weiner,1965). Weiner recognized the importance of the rapidly developing fields of control theory and systems analysis to problems in biology and medicine. During the ensuing decade, much was written about the potential benefits of applying mathematical analysis to biology (Yates et al., 1972).


Insulin Sensitivity Insulin Secretion Minimal Model Glucose Regulation Insulin Sensitivity Index 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Richard N. Bergman
    • 1
    • 2
  1. 1.Department of Physiology and Biophysics and USC Diabetes Research CenterUniversity of Southern CaliforniaLos Angeles
  2. 2.Department of Physiology and BiophysicsKeck-USC School of MedicineLos Angeles

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