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Endothelial Cell Biology: Inflammatory Biomarkers and Risk of Transplant Atherosclerosis

  • Carlos A. Labarrere
  • Beate R. Jaeger
Chapter

Abstract

During the past decade, major improvement in our understanding of the mechanisms for the development of atherosclerotic lesions has emerged. Inflammatory mechanisms seem to play a paramount role in the development of both the spontaneous as well the transplant associated forms of the disease1-18. The importance of inflammatory markers as predictors of spontaneous atherosclerosis has been clearly demonstrated by several publications in the recent years’-6Circulating plasma levels of markers of vascular inflammation seem to help with the identification of people at high risk for future cardiovascular events. The same seems to be the case for patients at risk of developing transplant atherosclerosis. Patients at risk for development of the disease also show a persistent elevation of biomarkers of inflammation in blood early following the transplant procedure’18.The present chapter will focus on the causative role of inflammation in the development of transplant atherosclerosis, the relationship between inflammation and procoagulation in the allograft microvasculature and how these changes relate to subsequent atherosclerosis, and the introduction of new therapies in order to delay or prevent the development of the disease and prolong transplant survival.

Keywords

Plasminogen Activator Tissue Plasminogen Activator Cardiac Allograft Tissue Factor Expression Cardiac Allograft Vasculopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Carlos A. Labarrere
    • 1
  • Beate R. Jaeger
    • 2
  1. 1.Methodist Research InstituteClarian Health Partners and Indiana University School of MedicineIndianapolisUSA
  2. 2.Institute for Clinical ChemistryUniversity Hospital GroßhadernMunichGermany

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