Abstract
This review focuses on the role of cerebral blood volume in the intracranial hemodynamics that may influence the pathophysiology of acute mountain sickness (AMS). Cerebral blood flow is elevated in acute hypoxia exposure in humans, but the response in this setting of cerebral blood volume is unknown. After discussing the background, attention is given to noninvasive measurement of cerebral blood volume, and recent preliminary data on cerebral blood volume in AMS
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References
Adams, R, M Victor, and A Ropper. Principles of Neurology: McGraw-Hill, 1997.
Alperin, NJ, SH Lee, F Loth, PB Raksin, and T Lichtor. MR-intracranial pressure (ICP): A method to measure intracranial elastance and pressure noninvasively by means of mr imaging: Baboon and human study Radiology 217: 877–885, 2000.
Angele, MK, MG Schwacha, N Smail, RA Catania, A Ayala, WG Cioffi, and IH Chaudry. Hypoxemia in the absence of blood loss upregulates iNos expression and activity in macro-phages. Am J Physiol 276: C285–290, 1999.
Barie, PS, JB Ghajar, AD Firlik, VA Chang, and RJ Hariri. Contribution of increased cerebral blood volume to posttraumatic intracranial hypertension. J Trauma 35: 88–95, 1993.
Baumgartner, RW, I Spyridopoulos, P Bartsch, M Maggiorini, and O Oelz. Acute mountain sickness is not related to cerebral blood flow: A decompression chamber study. J Appl Physiol 86: 1578–1582,1999.
Colier, WNJM. Near infrared spectroscopy: Toy or tool? An investigation on the clinical applicability of near infrared spectroscopy (Ph. D. ). Nijmegen: Catholic University of Ni-imegen, 1996.
Elwell, CE, M Cope, AD Edwards, JS Wyatt, DT Delpy, and EOR Reynolds. Quantification of adult cerebral hemodynamics by near-infrared spectroscopy. J Appl Physiol 77:2753–2760, 1994.
Fortune, JB, PJ Feustel, C deLuna, L Graca, J Hasselbarth, and AM Kupinski. Cerebral blood flow and blood volume in response to o2 and co2 changes in normal humans. J Trauma 39: 463–471, 1995.
Grubb, RL, Jr. , ME Raichle, JO Eichling, and MH Gado. Effects of subarachnoid hemorrhage on cerebral blood volume, blood flow, and oxygen utilization in humans. J Neurosurg 46: 446–453. 1977.
Grubb, RL, Jr. , ME Raichle, ME Phelps, and RA Ratcheson. Effects of increased intracranial pressure on cerebral blood volume, blood flow, and oxygen utilization in monkeys. J Neurosurg 43: 385–398, 1975.
Grubb, RL, ME Raichle, JO Eichling, and MM Ter-Pogossian. The effects of changes in paco2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 5: 630-639, 1974.
Hackett, P and RC Roach. High-altitude illness. New England Journal Medicine 345: 107–114, 2001.
Hartig, GS and PH Hackett. Cerebral spinal fluid pressure and cerebral blood velocity in acute mountain sickness. In: Hypoxia and mountain medicine, edited by Sutton JR, Coates G and Houston CS. Burlington, VT: Queen City Press, 1992, 260–265.
Kellie, G. Some reflections on the pathology of brain. Edinb Med Chir Soc Trans 1: 84–169, 1824.
Kobari, M, Y Fukuuchi, M Tomita, N Tanahashi, and H Takeda. Role of nitric oxide in regulation of cerebral microvascular tone and autoregulation of cerebral blood flow in cats. Brain Res 667: 255–262, 1994.
Krasney, JA. A neurogenic basis for acute altitude illness. Med Sci Sports Exerc 26: 195–208, 1994.
Marmarou, A, PP Fatouros, P Barzo, G Portella, M Yoshihara, O Tsuji, T Yamamoto, F Laine, S Signoretti, JD Ward, MR Bullock, and HF Young. Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients. J Neurosurg 93: 183–193. , 2000.
Marmarou, A, AL Maset, JD Ward, S Choi, D Brooks, HA Lutz, RJ Moulton, JP Muizelaar, A DeSalles, and HF Young. Contribution of csf and vascular factors to elevation of icp in severely head-injured patients. J Neurosurg 66: 883–890, 1987.
Mathew, NT, JS Meyer, and EO Ott. Increased cerebral blood volume in benign intracranial hypertension. Neurology 25: 646–649, 1975.
Monro, A. Observations on the structure and function of the nervous system: Printed for William Creek, 1783.
Newman, JP, DM Peebles, and MA Hanson. Adenosine produces changes in cerebral hemo-dynamics and metabolism as assessed by near-infrared spectroscopy in late-gestation fetal sheep in utero. Ped Res 50: 217–221, 2001.
Roach, RC and PH Hackett. Frontiers of hypoxia research: Acute mountain sickness. J Exp Biol 204: 3161–3170. , 2001.
Roach, RC, JA Loeppky, and MV Icenogle. Acute mountain sickness: Increased severity during simulated altitude compared with normobaric hypoxia. J Appl Physiol 81: 1908–1910, 1996.
Rostrup, E, I Law, F Pott, K Ide, and GM Knudsen. Cerebral hemodynamics measured with simultaneous pet and near-infrared spectroscopy in humans. Brain Res 954: 183–193, 2002.
Shapiro, K, A Marmarou, and K Shulman. Characterization of clinical csf dynamics and neu-ral axis compliance using the pressure-volume index: I. The normal pressure-volume index. Ann Neurol: 508–514. , 1980.
Singh, I, PK Khanna, MC Srivastava, M Lai, SB Roy, and CSV Subramanyam. Acute moun-tain sickness. N Engl J Med 280: 175–184, 1969.
Tsuji, M, A duPlessis, G Taylor, R Crocker, and JJ Volpe. Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets. Pediatr Res 44: 591–595. , 1998.
Van de Ven, MJ, WN Colier, MC van der Sluijs, D Walraven, B Oeseburg, and H Folgering. Can cerebral blood volume be measured reproducibly with an improved near infrared spectroscopy system? J Cereb Blood Flow Metab 21: 110–113, 2001.
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Mathew Kinsey, C., Roach, R. (2003). Role of Cerebral Blood Volume in Acute Mountain Sickness. In: Roach, R.C., Wagner, P.D., Hackett, P.H. (eds) Hypoxia. Advances in Experimental Medicine and Biology, vol 543. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8997-0_11
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DOI: https://doi.org/10.1007/978-1-4419-8997-0_11
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