Anatomical Studies of the Fibroblast Growth Factor-10 Mutant, Sonic Hedge Hog Mutant and Androgen Receptor Mutant Mouse Genital Tubercle

  • Selcuk Yucel
  • Wenhui Liu
  • Dwight Cordero
  • Anne Donjacour
  • Gerald Cunha
  • Laurence S. Baskin
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 545)


Congenital genital abnormalities have a diverse spectrum from hypospadias to cloacal anomalies. The molecular events in the normal and abnormal development of the genital tubercle (GT) are still obscure. Genetically engineered mice with specific gene deletions that affect genital anatomy are a useful tool to better understand the etiology of genital abnormalities. In this study, we compared the genital tubercle anatomy of the androgen receptor (AR) deficient, fibroblastic growth factor (FGF)-10 deficient and Sonic HedgeHog (Shh) deficient mutant male mice to that of the wild type male and female mouse.


Androgen Receptor Sonic Hedgehog Limb Development Urogenital Sinus Wild Type Male 
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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Selcuk Yucel
  • Wenhui Liu
  • Dwight Cordero
  • Anne Donjacour
  • Gerald Cunha
  • Laurence S. Baskin
    • 1
  1. 1.Department of UrologyUniversity of CaliforniaSan Francisco

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