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Hypospadias and Genital Development pp 217–241Cite as

Toxicant-Induced Hypospadias in the Male Rat

  • Conference paper

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 545))

Abstract

Prenatal exposure to endocrine disrupting chemicals that interfere with the androgen or insulin like factor 3 signaling pathways during sexual differentiation can induce malformations of the reproductive tract of the male rodent offspring. The pattern of malformations in the male depends upon the specific mechanism of action of the toxicant, the dosage level administered and the timing of administration during pregnancy. Hypospadias occurs in male rats or mice after maternal treatment with 1). potent estrogens or estrogenic drugs, 2). drugs that inhibit 5 alpha reductase, 3). drugs, herbicides and dicarboximide and conazole fungicides that act as androgen receptor (AR) antagonists, and 4). drugs, herbicides and conazole fungicides that inhibit cytochrome P450 enzymes involved in steroid hormone synthesis. In addition, 5). several phthalate diesters including di-n-butyl phthalate (DBP), di-n-ethylhexyl phthalate (DEHP), and benzylbutyl phthalate(BBP) also induce hypospadias and by altering fetal testis Leydig cell differentiation, resulting in reduced steroid and peptide hormone production.

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Authors and Affiliations

  1. MD-72, Endocrinology Branch, RTD, NHEERL, ORD, USEPA, RTP,, NC, 27711, USA

    L. Earl Gray Jr.

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  1. L. Earl Gray Jr.
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  2. Joseph Ostby
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  3. Johnathan Furr
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  4. Carmen Wolf
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  6. Vickie Wilson
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  7. Nigel Noriega
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  1. University of California, San Francisco, San Francisco, California, USA

    Laurence S. Baskin

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© 2004 Springer Science+Business Media New York

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Gray, L.E. et al. (2004). Toxicant-Induced Hypospadias in the Male Rat. In: Baskin, L.S. (eds) Hypospadias and Genital Development. Advances in Experimental Medicine and Biology, vol 545. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8995-6_14

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  • DOI: https://doi.org/10.1007/978-1-4419-8995-6_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4752-1

  • Online ISBN: 978-1-4419-8995-6

  • eBook Packages: Springer Book Archive

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