New Concepts on the Development of the Vagina
The female reproductive tract develops from the mullerian ducts. Mullerian duct development will not proceed in the absence of the mesonephric duct (Freedman and Shapiro, 1997; Gruenwald, 1943). The mullerian ducts adhere to each other just before they project into the dorsal wall of the urogenital sinus (UGS) causing an elevation termed the sinus tubercle. When the fused tips contact the sinus tubercle, the ducts fuse cranially, forming a tube with a single lumen called the uterovaginal primordium or canal (O’Rahilly, 1977). This tube will ultimately become the superior aspect of the vagina and uterus (Larsen, 1993). The cranial portion of the mullerian ducts which are unfused, develop into the fallopian tubes (George and Wilson, 1988). The original coelomic epithelial ostium remains as the abdominal opening of the fallopian tube. A septum initially divides the uterus into two cavities. This septum between the fused ducts disappears after 9 weeks, forming a single uterine cavity. The mesonephric ducts regress one week later, leaving a remnant in the female which is termed Gartner’s duct (Arey, 1974). Muscularization of the uterus is completed by 17 weeks gestation and forms from the mesenchyme surrounding the mullerian ducts.
KeywordsHydrogen Peroxide Microwave Estrogen Adenoma Testosterone
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- Acien, P., Arminana, E. and Garcia-Ontiveros, E., 1987, Unilateral renal agenesis associated with ipsilateral blind vagina, Arch. Path. 240, 1.Google Scholar
- Arey, L.B., 1974, Developmental anatomy, 7th edition, W.B. Saunders Co., Philadelphia.Google Scholar
- Freedman, A. L. and Shapiro, E., 1997, The embryological basis of genitourinary malformations. in: Urological Disease of the Fetus and Infant. D.F.M. Thomas (ed.), Butterworth Heinemann, Oxford, Chapter 2, pp 24–37.Google Scholar
- George, F. W. and Wilson, J. D. 1988, Sex determination and differentiation. in: E. Kobel, ed. The Physiology of Reproduction, New York: Raven Press, 3–26.Google Scholar
- Gray, S. W., Skandalakis, J. E., and Broecker, B., 1994, The female reproductive tract. IN: J. E. Skandalakis and S. W. Gray, eds. Embryology for Surgeons, 2nd edition. Baltimore: Williams and Wilkins, Chapter 22,816–847.Google Scholar
- Grumbach, M. M. and Conte, F. A., 1992, Disorders of sex differentiation. In: Jean D. Wilson and Daniel W. Foster, eds. Williams Textbook of Endocrinology, 8th edition. Philadelphia: W.B. Saunders, Chapter 18, 853–951.Google Scholar
- Hart, D. B., 1911, Adenoma vaginae diffusum (adenomatosis vaginae) with a critical discussion of present views of vaginal hymenal development, Edinb. Med. J. 6: 577–590.Google Scholar
- Hunter, R.H.,1930, Observations on the development of the human female genital tract, Contrib. Embryol. Carnegie Inst. Wash.,22:91–108.Google Scholar
- Koff, A. K., 1933, Development of the vagina in the human foetus. Contrib. Embryol. Carnegie Inst. Wash., 24: 61–90.Google Scholar
- Larsen, W. J., 1993, Human Embryology. Churchill Livingstone, New York.Google Scholar
- O’Rahilly, R., 1977, The development of the vagina in the human. Birth Defects: Original Article Series, 13: 123–136.Google Scholar
- Wu, X.-R., Manabe M, Yu, J., Sun, T. T., 1990, Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation, J. Biol. Chem. 265(31): 19179.Google Scholar